PTRF antibody (C-Term)
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- Target See all PTRF Antibodies
- PTRF (Polymerase I and Transcript Release Factor (PTRF))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PTRF antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- At least three isoforms of PTRF are known to exist, this antibody detects all three isoforms. It is predicted to not cross-react with other members of the cavin family.
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- Rabbit polyclonal PTRF antibody was raised against a 19 amino acid peptide near the carboxy terminus of human PTRF.
- Isotype
- IgG
- Top Product
- Discover our top product PTRF Primary Antibody
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- Application Notes
- PTRF antibody can be used for detection of PTRF by Western blot at 0.5 - 1 μg/mL.
- Comment
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(CT) Polymerase I and transcript release factor
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Storage
- 4 °C/-20 °C
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- Target
- PTRF (Polymerase I and Transcript Release Factor (PTRF))
- Alternative Name
- PTRF (PTRF Products)
- Synonyms
- MGC53017 antibody, MGC89141 antibody, PTRF antibody, fd20g07 antibody, ptrf antibody, wu:fd20g07 antibody, zgc:162917 antibody, CAVIN antibody, CAVIN1 antibody, CGL4 antibody, cavin-1 antibody, 2310075E07Rik antibody, AW546441 antibody, Cav-p60 antibody, Cavin antibody, caveolae associated protein 1 L homeolog antibody, polymerase I and transcript release factor antibody, caveolae associated protein 1 antibody, caveolae associated protein 1b antibody, caveolae associated 1 antibody, cavin1.L antibody, PTRF antibody, cavin1 antibody, CAVIN1 antibody, cavin1b antibody, Cavin1 antibody
- Background
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The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
Synonyms: Polymerase I and transcript release factor, FKSG13, CAVIN, CAVIN1, CGL4, cavin-1, TTF-I interacting peptide 12 - Molecular Weight
- 43 kDa
- Gene ID
- 284119
- NCBI Accession
- NP_036364
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