RC3H1 antibody (C-Term)
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- Target See all RC3H1 Antibodies
- RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This RC3H1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- At least three isoforms of RC3H1 are known to exist, this antibody will detect all three isoforms.
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- Rabbit polyclonal RC3H1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RC3H1.
- Isotype
- IgG
- Top Product
- Discover our top product RC3H1 Primary Antibody
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- Application Notes
- RC3H1 antibody can be used for detection of RC3H1 by Western blot at 1 - 2 μg/mL.
- Comment
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(CT) Ring finger and CCCH-type domains 1
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Storage
- 4 °C/-20 °C
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- Target
- RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))
- Alternative Name
- RC3H1 (RC3H1 Products)
- Synonyms
- RNF198 antibody, ROQUIN antibody, RC3H1 antibody, si:dkey-192m14.4 antibody, 5730557L09Rik antibody, Gm551 antibody, N28103 antibody, mKIAA2025 antibody, RGD1563512 antibody, rc3h1 antibody, ring finger and CCCH-type domains 1 antibody, ring finger and CCCH-type domains 1a antibody, ring finger and CCCH-type zinc finger domains 1 antibody, RING CCCH (C3H) domains 1 antibody, ring finger and CCCH-type domains 1 L homeolog antibody, RC3H1 antibody, rc3h1a antibody, Rc3h1 antibody, rc3h1.L antibody
- Background
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The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
Synonyms: Ring finger and CCCH-type domains 1, ring finger protein 198, RNF198, roquin - Molecular Weight
- 125 kDa
- Gene ID
- 149041
- NCBI Accession
- NP_742068
- Pathways
- Ribonucleoprotein Complex Subunit Organization, Activated T Cell Proliferation
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