TSPY1S (C-Term) antibody
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- Target
- TSPY1S
- Binding Specificity
- C-Term
- Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
- Application
- ELISA, Western Blotting (WB)
- Specificity
- TSPY1S antibody is human and mouse reactive. At least three isoforms of TSPY1 are known to exist, this antibody will detect only TSPY1S
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- Rabbit polyclonal TSPY1S antibody was raised against a 13 amino acid peptide near the carboxy terminus of human TSPY1S.
- Isotype
- IgG
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- Application Notes
- TSPY1S antibody can be used for detection of TSPY1S by Western blot at 1 - 2 μg/mL.
- Comment
-
(CT) Testis specific protein Y-linked 1 small isoform
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Storage
- 4 °C
- Storage Comment
- TSPY1S antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.
- Expiry Date
- 12 months
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- Target
- TSPY1S
- Background
-
Testis-specific protein on Y chromosome (TSPY1) is an ampliconic gene on the Y chromosome that has been associated with gonadoblastoma. Recent experiments have shown that in androgen-dependent testicular germ-cell tumors, TSPY1 can repress the androgen-bound androgen receptor (AR), a member of the nuclear steroid hormone receptor family that acts as a ligand-inducible transcription factor, suggesting that TSPY1 is a repressor of cell proliferation in germ-cell tumors and potentially in normal gonadal cells during early development. Two distinct isoforms of TSPY1, TSPY1L and TSPY1S, are known to exist.
Synonyms: Testis specific protein Y-linked 1 small isoform, TSPY, CT78, DYS14, pJA923 - Molecular Weight
- 32 kDa
- Gene ID
- 7258
- NCBI Accession
- NP_001184171
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