IDO2 antibody

Catalog No. ABIN1043821

Product Details anti-IDO2 Antibody

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This IDO2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Anti-IDO2 was purified from concentrated tissue culture supernate by Protein G chromatography followed by extensive dialysis against the buffer stated above. IDO2 antibody is specific for mouse IDO2 protein. Cross-reactivity with IDO2 from other sources has not been determined.

Characteristics: Indoleamine 2,3-dioxygenase 2 (IDO2) is related to IDO1, and may play a role in T and B Cell Immunity. IDO2’s role in immune regulation will be become clearer following the completion of genetic knock-out studies. IDO2 is expressed in a few select cell types and levels of protein expression appear to be very low, perhaps below the level of detection by IHC. Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being translated to clinic for evaluation as cancer therapeutics.

Sterility: Sterile filtered

Immunogen: Anti-IDO2 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with complete mouse IDO2 protein followed by hybridoma development.
Immunogen Type: Recombinant Protein

Clone: 1HC

Isotype: IgG

Application Details

Application Notes: Anti-IDO2 antibody has been tested for use in ELISA, Western Blot, and IF. Specific conditions for reactivity should be optimized by the end user.

Comment:

Gene Name: Ido2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Expiry Date: 12 months

References for anti-IDO2 antibody (ABIN1043821)

Wolff, Driever, Erdlenbruch, Kortmann, Rutkowski, Pietsch, Parker, Metz, Gnekow, Kramm: "Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol." in: Cancer, Vol. 116, Issue 3, pp. 705-12, (2010) (PubMed).

Metz, Duhadaway, Rust, Munn, Muller, Mautino, Prendergast: "Zinc protoporphyrin IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase." in: Molecular cancer therapeutics, Vol. 9, Issue 6, pp. 1864-71, (2010) (PubMed).

Target Details for IDO2

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Alternative Name: IDO2 (IDO2 Products)

Synonyms: INDOL1 antibody, Indol1 antibody, AI265623 antibody, C230043N17Rik antibody, Ido-2 antibody, indoleamine 2,3-dioxygenase 2 antibody, IDO2 antibody, Ido2 antibody

Background: Indoleamine 2,3-dioxygenase 2 (IDO2) is related to IDO1, and may play a role in T and B Cell Immunity. IDO2’s role in immune regulation will be become clearer following the completion of genetic knock-out studies. IDO2 is expressed in a few select cell types and levels of protein expression appear to be very low, perhaps below the level of detection by IHC. Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being translated to clinic for evaluation as cancer therapeutics.
Synonyms: Indoleamine 2,3-dioxygenase 2, Indol1, Indoleamine 2,3-dioxygenase-like protein 1, Indoleamine-pyrrole 2,3-dioxygenase-like protein 1, Ido-2, Ido 2, IDO2 antibody, anti-IDO2 antibody

Gene ID: 209176

NCBI Accession: NP_666061

UniProt: Q8R0V5