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IL17F antibody

Rockland 209-301-b31 IL17F Reactivity: Human WB, ELISA, IHC Host: Mouse Monoclonal 4H1629-1 unconjugated
Rockland
Catalog No. ABIN1043779
Supplier Product No.: 209-301-b31
  • Target See all IL17F Antibodies
    IL17F (Interleukin 17F (IL17F))
    Reactivity
    • 75
    • 30
    • 18
    Human
    Host
    • 79
    • 19
    • 2
    Mouse
    Clonality
    • 82
    • 17
    • 1
    Monoclonal
    Conjugate
    • 54
    • 11
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL17F antibody is un-conjugated
    Application
    • 67
    • 49
    • 22
    • 21
    • 8
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Supplier Product No.
    209-301-b31
    Supplier
    Rockland
    Purpose
    IL-17F Antibody
    Cross-Reactivity (Details)
    This antibody is specific for human IL-17F protein.
    Characteristics
    Synonyms: mouse anti-IL-17F antibody, mouse anti-Interleukin-17F antibody, Cytokine ML-1, Interleukin-24
    Purification
    Anti-Human IL-17F (MOUSE) Monoclonal Antibody was purified from concentrated tissue culture supernate by Protein G chromatography followed by extensive dialysis against the buffer stated above.
    Sterility
    Sterile filtered
    Immunogen

    Immunogen: Anti-IL-17F (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with mature full length recombinant human IL-17F produced in E.coli followed by hybridoma development.

    Immunogen Type: Recombinant Protein

    Clone
    4H1629-1
    Isotype
    IgG1
    Top Product
    Discover our top product IL17F Primary Antibody
  • Application Notes

    Immunohistochemistry Dilution: 5 μg/mL

    Application Note: Anti-Human IL-17F antibody has been tested for use in IHC and Western Blot. Specific conditions for reactivity should be optimized by the end user.

    Western Blot Dilution: 0.5 μg/mL

    ELISA Dilution: 1:10,000-1:50,000

    Other: User Optimized

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0mg/mL
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Expiry Date
    12 months
  • Conti, Shen, Nayyar, Stocum, Sun, Lindemann, Ho, Hai, Yu, Jung, Filler, Masso-Welch, Edgerton, Gaffen: "Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis." in: The Journal of experimental medicine, Vol. 206, Issue 2, pp. 299-311, (2009) (PubMed).

  • Target
    IL17F (Interleukin 17F (IL17F))
    Alternative Name
    IL17F (IL17F Products)
    Background
    Background: Anti-L-17F recognizes IL-17F (also known as Cytokine ML-1 or Interleukin-24). IL-17F is produced and secreted by CD8+ T cells, NK cells, NKT cells and LTi cells. The main functions of IL-17F are neutrophil recruitment and immunity to extracellular pathogen. More importantly, IL-17F drives inflammation and auto-immunity. IL-17A and IL-17F are by far the best characterized cytokines of the IL-17 cytokine family. IL-17F dimerizes in a parallel fashion similar to nerve growth factor and other neutrophins. Its dimerization is critical to fulfill its activity. When secreted by activated T cells, IL-17F can stimulate the production of other cytokines such as IL-6, IL-8 granulocyte colony-stimulating factor and, can stimulate cartilage matrix turnover. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. Anti-IL-17E cytokine antibody is ideal for investigators involved in Immunology, Signal Transduction research, Cancer and Inflammatory pathologies.
    Gene ID
    112744
    NCBI Accession
    NP_443104
    UniProt
    Q96PD4
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity
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