ADAM17 antibody (C-Term)

Catalog No. ABIN1030720

Product Details anti-ADAM17 Antibody

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: 80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated TACE.

Purification: Affinity chromatography purified via peptide column

Application Details

Application Notes: TACE antibody can be used for detection of TACE by Western blot at 0.5 - 1 μg/mL. For immunocytochemistry use 10 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-ADAM17 antibody (ABIN1030720)

McGowan, Mullooly, Caiazza, Sukor, Madden, Maguire, Pierce, McDermott, Crown, ODonovan, Duffy: "ADAM-17: a novel therapeutic target for triple negative breast cancer." in: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 24, Issue 2, pp. 362-9, (2013) (PubMed).

Target Details for ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Alternative Name: TACE (ADAM17 Products)

Molecular Weight: Predicted: 93 kDa

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus