ANK2 Products
(Ankyrin 2, Neuronal (ANK2))
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This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats\; a central region with a highly conserved spectrin binding domain\; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011].
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Featured ANK2 Categories
ANK2 Antibodies
High quality antibodies with extensive validation data.
ANK2 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended ANK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IF
Validations
- (4)
Cat. No.
ABIN1027715
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN2485091
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN2485090
Quantity
100 μg
Datasheet
Datasheet
Recommended ANK2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN770590
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative
Validations
Cat. No.
ABIN778171
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rabbit
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN774272
Quantity
96 tests
Datasheet
Datasheet
Recommended ANK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2714726
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our ANK2 products
: "Glial ankyrins facilitate paranodal axoglial junction assembly." in: Nature neuroscience, Vol. 17, Issue 12, pp. 1673-81, (2014) (PubMed).: "In vivo assembly of the axon initial segment in motor neurons." in: Brain structure & function, Vol. 219, Issue 4, pp. 1433-50, (2014) (PubMed).
: "AlphaII-spectrin participates in the surface expression of cell adhesion molecule L1 and neurite outgrowth." in: Experimental cell research, Vol. 322, Issue 2, pp. 365-80, (2014) (PubMed).
: "Proteomic analysis of gliosomes from mouse brain: identification and investigation of glial membrane proteins." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5918-27, (2014) (PubMed).
: "A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier." in: Nature neuroscience, Vol. 17, Issue 12, pp. 1664-72, (2014) (PubMed).
: "Membrane domain organization of myelinated axons requires ?II spectrin." in: The Journal of cell biology, Vol. 203, Issue 3, pp. 437-43, (2013) (PubMed).
: "A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly." in: Cell, Vol. 149, Issue 5, pp. 1125-39, (2012) (PubMed).
: "Real-time CARS imaging reveals a calpain-dependent pathway for paranodal myelin retraction during high-frequency stimulation." in: PLoS ONE, Vol. 6, Issue 3, pp. e17176, (2011) (PubMed).
: "Schwann cell spectrins modulate peripheral nerve myelination." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 19, pp. 8009-14, (2011) (PubMed).
: "Molecular microdomains in a sensory terminal, the vestibular calyx ending." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 27, pp. 10101-14, (2011) (PubMed).
Synonyms and alternative names related to ANK2
ankyrin 2 (ANK2), ankyrin 2, brain (Ank2), ankyrin 2 (Ank2), ankyrin-2 (LOC539238), ankyrin 2b, neuronal (ank2b), ankyrin-2 (LOC100465763), AI835472, ANK-2, Ank-2, ANK2, ank2, Ank3, ANKB, AW491075, brank-2, CHANK2, LQT4, zgc:101738Protein level used designations for ANK2
- ankyrin B
- ankyrin, brain
- ankyrin-2
- ankyrin-2, nonerythrocytic
- non-erythroid ankyrin
- ankyrin-B
- brain ankyrin
- ankyrin 2, brain
- ankyrin 3, epithelial
- ankyrin 2, neuronal
- ankyrin-2-like
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