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ANGL4 Protein (AA 28-403, partial) (GST tag)

ANGL4 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Catalog No. ABIN5712720
  • Target
    ANGL4 (Angiopoietin-Related Protein 4 (ANGL4))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 28-403, partial
    Origin
    Human
    Source
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This ANGL4 protein is labelled with GST tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    VQSKSPRFAS WDEMNVLAHG LLQLGQGLRE HAERTRSQLS ALERRLSACG SACQGTEGST DLPLAPESRV DPEVLHSLQT QLKAQNSRIQ QLFHKVAQQQ RHLEKQHLRI QHLQSQFGLL DHKHLDHEVA KPARRKRLPE MAQPVDPAHN VSRLHRLPRD CQELFQVGER QSGLFEIQPQ GSPPFLVNCK MTSDGGWTVI QRRHDGSVDF NRPWEAYKAG FGDPHGEFWL GLEKVHSITG DRNSRLAVQL RDWDGNAELL QFSVHLGGED TAYSLQLTAP VAGQLGATTV PPSGLSVPFS TWDQDHDLRR DKNCAKSLSG GWWFGTCSHS NLNGQYFRSI PQQRQKLKKG IFWKTWRGRY YPLQATTMLI QPMAAE
    Purification
    SDS-PAGE
    Purity
    > 90 %
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Storage
    -80 °C,4 °C,-20 °C
    Storage Comment
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    ANGL4 (Angiopoietin-Related Protein 4 (ANGL4))
    Alternative Name
    ANGL4
    Background
    Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation .
    Molecular Weight
    69.9 kDa
    UniProt
    Q9BY76
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