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Amylin/DAP Products

(Islet Amyloid Polypeptide (IAPP))

Amylin, also known as islet amyloid polypeptide (IAPP), is a peptide hormone primarily produced by pancreatic beta cells. It plays several important roles in regulating glucose metabolism and satiety. Here are the major cellular mechanisms in which amylin is involved:

  • Glucose Regulation and Delayed Absorption: Amylin helps regulate blood glucose levels by slowing down the emptying of the stomach, delaying glucose absorption, and reducing post-meal blood sugar spikes.
  • Appetite Control and Satiety: Amylin acts in the brain to induce feelings of fullness and reduce food intake, contributing to appetite control and weight management.
  • Inhibition of Glucagon and Insulin Sensitivity: Amylin inhibits glucagon secretion, helping to maintain glucose homeostasis, and may enhance insulin sensitivity in peripheral tissues, aiding in overall metabolic health.

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Featured Amylin/DAP Categories

Amylin/DAP Antibodies

High quality antibodies with extensive validation data.

Amylin/DAP ELISA Kits

Reliable ELISA kits for a wide range of species.

Amylin/DAP Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Amylin/DAP Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7426055
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, WB, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6259921
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC
Validations
  • (2)
Cat. No. ABIN7157084
Quantity 100 μg
Datasheet Datasheet

Recommended Amylin/DAP ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957220
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968064
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968062
Quantity 96 tests
Datasheet Datasheet

Recommended Amylin/DAP Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123638
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307318
Quantity 25 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7392188
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Amylin/DAP products

Rosas, Nagaraja, Kaur, Panossian, Wickman, Garcia, Al-Khamis, Asea: "Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment." in: PLoS ONE, Vol. 11, Issue 3, pp. e0149409, (2016) (PubMed).

El Assar, Angulo, Santos-Ruiz, Moreno, Novials, Villanueva-Peñacarrillo, Rodríguez-Mañas: "Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120479, (2015) (PubMed).

Guan, Chow, Song, Verma, Despa, Hersh: "The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells." in: PLoS ONE, Vol. 10, Issue 7, pp. e0133263, (2015) (PubMed).

Ladiwala, Bhattacharya, Perchiacca, Cao, Raleigh, Abedini, Schmidt, Varkey, Langen, Tessier: "Rational design of potent domain antibody inhibitors of amyloid fibril assembly." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 49, pp. 19965-70, (2012) (PubMed).

Gurlo, Ryazantsev, Huang, Yeh, Reber, Hines, OBrien, Glabe, Butler: "Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway." in: The American journal of pathology, Vol. 176, Issue 2, pp. 861-9, (2010) (PubMed).

Zhao, Guan, Lee, Sui, He, Siu, Tse, Tong, Lai, Chan: "Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition." in: Pancreas, Vol. 39, Issue 6, pp. 843-6, (2010) (PubMed).

Zheng, Ren, Zhang, Liu, Li, Li, Yang, He, Su, Li: "Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus." in: Acta diabetologica, Vol. 47, Issue 3, pp. 265-70, (2010) (PubMed).

Nakamura, Okabayashi, Ageyama, Koie, Sankai, Ono, Fujimoto, Terao: "Transthyretin amyloidosis and two other aging-related amyloidoses in an aged vervet monkey." in: Veterinary pathology, Vol. 45, Issue 1, pp. 67-72, (2008) (PubMed).

Zhao, Sui, Guan, He, Gu, Wong, Baum, Lai, Tong, Chan: "Amyloid oligomers in diabetic and nondiabetic human pancreas." in: Translational research : the journal of laboratory and clinical medicine, Vol. 153, Issue 1, pp. 24-32, (2008) (PubMed).

Bhattacharya, Latha, Kumresan, Singh: "Cloning and expression of human islet amyloid polypeptide in cultured cells." in: Biochemical and biophysical research communications, Vol. 356, Issue 3, pp. 622-8, (2007) (PubMed).

Synonyms and alternative names related to Amylin/DAP

islet amyloid polypeptide (IAPP), islet amyloid polypeptide (Iapp), Amylin, DAP, IAP, LOC100230121

Protein level used designations for Amylin/DAP

  • Islet amyloid polypeptide (diabetes-associated peptide; amylin)
  • amylin
  • diabetes-associated peptide
  • insulinoma amyloid peptide
  • DAP
  • islet amyloid polypeptide
  • amyloid protein
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