Aminoacylase 1 Products
(Aminoacylase 1 (ACY1))
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This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010].
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Featured Aminoacylase 1 Categories
Aminoacylase 1 Antibodies
High quality antibodies with extensive validation data.
Aminoacylase 1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Aminoacylase 1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Aminoacylase 1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IP, IHC (p)
Validations
- (1)
- (6)
Cat. No.
ABIN559777
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7434791
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Mouse, Rat
Application
WB, IHC, FACS, IHC (p)
Validations
- (6)
Cat. No.
ABIN1496452
Quantity
100 μL
Datasheet
Datasheet
Recommended Aminoacylase 1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953660
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4881733
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730070
Quantity
96 tests
Datasheet
Datasheet
Recommended Aminoacylase 1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305823
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121810
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121809
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Aminoacylase 1 products
: "Profiling of antibody production against xenograft-released proteins by protein microarrays discovers prostate cancer markers." in: Journal of proteome research, Vol. 11, Issue 2, pp. 728-35, (2012) (PubMed).: "The molecular basis of aminoacylase 1 deficiency." in: Biochimica et biophysica acta, Vol. 1812, Issue 6, pp. 685-90, (2011) (PubMed).
: "Acylase 1 expression in rat intestinal crypt--villus axis." in: Cell biology international, Vol. 31, Issue 9, pp. 966-73, (2007) (PubMed).
: "Aminoacylase I deficiency: a novel inborn error of metabolism." in: Biochemical and biophysical research communications, Vol. 338, Issue 3, pp. 1322-6, (2005) (PubMed).
Synonyms and alternative names related to Aminoacylase 1
aminoacylase 1 (ACY1), aminoacylase 1 (acy1), aminoacylase 1, gene 1 S homeolog (acy1.1.S), aminoacylase 1, gene 1 (acy1.1), aminoacylase 1 (Acy1), 1110014J22Rik, ACY-1, Acy-1, acy1, ACY1, Acy1a, Acy1b, acy1d, ACY1D, acylase, si:zfos-226g1.1, zgc:55605, zgc:76955Protein level used designations for Aminoacylase 1
- aminoacylase-1
- aminoacylase 1
- N-acyl-L-amino-acid amidohydrolase
- acylase
- ACY IA
- ACY IB
- ACY-1A
- ACY-1B
- aminoacylase-1A
- aminoacylase-1B
- ACY-1
- N-acylamino acid aminohydrolase (Aminoacylase 1)
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