ALPL Products
(Alkaline Phosphatase, Liver/bone/kidney (ALPL))
Categories
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].
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Featured ALPL Categories
ALPL Antibodies
High quality antibodies with extensive validation data.
ALPL ELISA Kits
Reliable ELISA kits for a wide range of species.
ALPL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ALPL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7433150
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (2)
- (5)
Cat. No.
ABIN969500
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Human
Application
IHC, StM
Validations
- (5)
Cat. No.
ABIN6939448
Quantity
100 μg
Datasheet
Datasheet
Recommended ALPL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6963030
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
- (1)
Cat. No.
ABIN6960610
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rabbit
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6973340
Quantity
96 tests
Datasheet
Datasheet
Recommended ALPL Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121791
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344939
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344937
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ALPL products
: "Effect of herbal extract Eurycoma longifolia (Physta®) on female reproductive hormones and bone biochemical markers: an ovariectomised rat model study." in: BMC complementary medicine and therapies, Vol. 20, Issue 1, pp. 31, (2020) (PubMed).: "Smart Nanosacrificial Layer on the Bone Surface Prevents Osteoporosis through Acid-Base Neutralization Regulated Biocascade Effects." in: Journal of the American Chemical Society, Vol. 142, Issue 41, pp. 17543-17556, (2020) (PubMed).
: "Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration." in: Cell stem cell, Vol. 24, Issue 2, pp. 240-256.e9, (2019) (PubMed).
: "Activation of cancer-related and mitogen-activated protein kinase signaling pathways in human mature osteoblasts isolated from patients with type 2 diabetes." in: Bone reports, Vol. 10, pp. 100199, (2019) (PubMed).
: "Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells." in: International journal of molecular sciences, Vol. 20, Issue 5, (2019) (PubMed).
: "Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ." in: Scientific reports, Vol. 9, Issue 1, pp. 6688, (2019) (PubMed).
: "Silent Mating Type Information Regulation 2 Homolog (SIRT1) Influences Osteogenic Proliferation and Differentiation of MC3T3-E1 Cells via Regulation of miR-132-3p." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 25, pp. 2289-2295, (2019) (PubMed).
: "Osteosarcoma cell-derived exosomes affect tumor microenvironment by specific packaging of microRNAs." in: Carcinogenesis, (2019) (PubMed).
: "Protective Effects of Melon Extracts on Bone Strength, Mineralization, and Metabolism in Rats with Ovariectomy-Induced Osteoporosis." in: Antioxidants (Basel, Switzerland), Vol. 8, Issue 8, (2019) (PubMed).
: "FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts." in: Scientific reports, Vol. 7, Issue 1, pp. 3345, (2018) (PubMed).
Synonyms and alternative names related to ALPL
alkaline phosphatase, liver/bone/kidney L homeolog (alpl.L), alkaline phosphatase, liver/bone/kidney (ALPL), alkaline phosphatase, intestinal, gene 2 (alpi.2), alkaline phosphatase, liver/bone/kidney pseudogene (LOC100031702), alkaline phosphatase, liver/bone/kidney (Alpl), Akp-2, Akp2, ALP, alpl, AP-TNAP, APTNAP, HOPS, iap, PHOA, TNAP, TNS-AP, TNSALPProtein level used designations for ALPL
- tissue-nonspecific alkaline phosphatase
- alkaline phosphatase, tissue-nonspecific isozyme
- tissue non-specific alkaline phosphatase
- alkaline phosphatase, liver/bone/kidney
- alkaline phosphatase, tissue-nonspecific isozyme-like
- alkaline phosphatase liver/bone/kidney isozyme
- alkaline phosphomonoesterase
- glycerophosphatase
- liver/bone/kidney-type alkaline phosphatase
- tissue-nonspecific ALP
- alkaline phosphatase 2, liver
- AP-TNAP
- TNSALP
- Tissue-nonspecific ALP alkaline phosphatase
- alkaline phosphatase tissue non-specific isoform
- liver/bone/kidney isozyme
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