alpha Adaptin Products
(Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))
Categories
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008].
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Featured alpha Adaptin Categories
alpha Adaptin Antibodies
High quality antibodies with extensive validation data.
alpha Adaptin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended alpha Adaptin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (5)
Cat. No.
ABIN5539681
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (3)
Cat. No.
ABIN6136952
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN7101684
Quantity
20 μL
Datasheet
Datasheet
Recommended alpha Adaptin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6212658
Quantity
96 tests
Datasheet
Datasheet
Recommended alpha Adaptin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121699
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345241
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3088890
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our alpha Adaptin products
: "Quantitative proteomics reveals reduction of endocytic machinery components in gliomas." in: EBioMedicine, Vol. 46, pp. 32-41, (2020) (PubMed).: "Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid ..." in: Molecular & cellular proteomics : MCP, Vol. 17, Issue 1, pp. 146-159, (2019) (PubMed).
: "Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation." in: The Journal of biological chemistry, Vol. 287, Issue 12, pp. 9429-40, (2012) (PubMed).
: "Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 12447-58, (2009) (PubMed).
: "Endocytosis of synaptotagmin 1 is mediated by a novel, tryptophan-containing motif." in: Traffic (Copenhagen, Denmark), Vol. 4, Issue 7, pp. 468-78, (2003) (PubMed).
: "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics." in: The Journal of cell biology, Vol. 158, Issue 5, pp. 855-62, (2002) (PubMed).
: "Numb is an endocytic protein." in: The Journal of cell biology, Vol. 151, Issue 6, pp. 1345-52, (2001) (PubMed).
: "The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis." in: The Journal of cell biology, Vol. 154, Issue 4, pp. 857-66, (2001) (PubMed).
: "The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors." in: The Journal of biological chemistry, Vol. 276, Issue 21, pp. 18392-8, (2001) (PubMed).
: "The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis." in: Human molecular genetics, Vol. 10, Issue 17, pp. 1807-17, (2001) (PubMed).
Synonyms and alternative names related to alpha Adaptin
adaptor related protein complex 2 alpha 1 subunit (AP2A1), adaptor related protein complex 2 alpha 1 subunit (ap2a1), adaptor-related protein complex 2, alpha 1 subunit (Ap2a1), AP-2 complex subunit alpha-1 (EDI_093420), AP-2 complex subunit alpha-1 (EDI_259990), adaptor related protein complex 2 alpha 1 subunit (Ap2a1), ADTAA, adtaa, Adtaa, AP2-ALPHA, ap2-alpha, AP2A1, CLAPA1, clapa1Protein level used designations for alpha Adaptin
- 100 kDa coated vesicle protein A
- AP-2 complex subunit alpha-1
- adapter-related protein complex 2 alpha-1 subunit
- adaptin, alpha A
- adaptor protein complex AP-2 subunit alpha-1
- alpha-adaptin A
- alpha1-adaptin
- clathrin assembly protein complex 2 alpha-A large chain
- clathrin-associated/assembly/adaptor protein, large, alpha 1
- plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
- adaptor protein complex AP-2, alpha 1 subunit
- adaptor-related protein complex 2, alpha 1 subunit
- AP-2 complex subunit alpha-1-like
- adaptor-related protein complex AP-2, alpha 1 subunit
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