alpha Actinin 4 Products
(Actinin, alpha 4 (ACTN4))
Categories
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008].
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Featured alpha Actinin 4 Categories
alpha Actinin 4 Antibodies
High quality antibodies with extensive validation data.
alpha Actinin 4 ELISA Kits
Reliable ELISA kits for a wide range of species.
alpha Actinin 4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended alpha Actinin 4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (1)
- (12)
Cat. No.
ABIN559759
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7440797
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (7)
Cat. No.
ABIN2855119
Quantity
100 μL
Datasheet
Datasheet
Recommended alpha Actinin 4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964559
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953411
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1121247
Quantity
96 tests
Datasheet
Datasheet
Recommended alpha Actinin 4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1305772
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121665
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305774
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our alpha Actinin 4 products
: "Alpha-Actinin-4 is a Possible Target Protein for Aristolochic Acid I in Human Kidney Cells In Vitro." in: The American journal of Chinese medicine, Vol. 44, Issue 2, pp. 291-304, (2016) (PubMed).: "Identification of protein biomarkers for cervical cancer using human cervicovaginal fluid." in: PLoS ONE, Vol. 9, Issue 9, pp. e106488, (2014) (PubMed).
: "α-Actinin-4 is required for amoeboid-type invasiveness of melanoma cells." in: The Journal of biological chemistry, Vol. 289, Issue 47, pp. 32717-28, (2014) (PubMed).
: "The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration." in: PLoS pathogens, Vol. 8, Issue 10, pp. e1002953, (2012) (PubMed).
: "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy." in: Journal of proteomics, Vol. 75, Issue 7, pp. 2236-51, (2012) (PubMed).
: "Angiogenin enhances cell migration by regulating stress fiber assembly and focal adhesion dynamics." in: PLoS ONE, Vol. 6, Issue 12, pp. e28797, (2011) (PubMed).
: "RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma." in: International journal of oral and maxillofacial surgery, Vol. 39, Issue 1, pp. 61-7, (2010) (PubMed).
: "Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96." in: The Journal of biological chemistry, Vol. 285, Issue 1, pp. 197-205, (2009) (PubMed).
: "Targets of caspase-6 activity in human neurons and Alzheimer disease." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 8, pp. 1541-55, (2008) (PubMed).
: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).
Synonyms and alternative names related to alpha Actinin 4
actinin alpha 4 (actn4), actinin alpha 4 (ACTN4), actinin alpha 4 (Actn4), actinin, alpha 4 (actn4), actinin alpha 4 S homeolog (actn4.S), actinin, alpha 4 (ACTN4), ACTININ-4, C77391, fsgs, FSGS, fsgs1, FSGS1, wu:fb53f05, zgc:63508Protein level used designations for alpha Actinin 4
- actinin, alpha 4
- alpha-actinin-4-like
- F-actin cross-linking protein
- alpha-actinin-4
- non-muscle alpha-actinin 4
- alpha actinin 4
- actinin alpha4 isoform
- focal segmental glomerulosclerosis 1
- alpha-actinin
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