ALOX5 Products
(Arachidonate 5-Lipoxygenase (ALOX5))
Categories
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
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Featured ALOX5 Categories
ALOX5 Antibodies
High quality antibodies with extensive validation data.
ALOX5 ELISA Kits
Reliable ELISA kits for a wide range of species.
ALOX5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ALOX5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7433525
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (5)
Cat. No.
ABIN513267
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN3023073
Quantity
100 μL
Datasheet
Datasheet
Recommended ALOX5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6953906
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964998
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964995
Quantity
96 tests
Datasheet
Datasheet
Recommended ALOX5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344921
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7393886
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7424545
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ALOX5 products
: "Modulating effect of inositol hexaphosphate on arachidonic acid-dependent pathways in colon cancer cells." in: Prostaglandins & other lipid mediators, Vol. 131, pp. 41-48, (2018) (PubMed).: "BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils." in: Scientific reports, Vol. 6, pp. 29650, (2016) (PubMed).
: "Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study." in: Atherosclerosis, Vol. 239, Issue 2, pp. 528-38, (2015) (PubMed).
: "The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats." in: Behavioral and brain functions : BBF, Vol. 11, pp. 18, (2015) (PubMed).
: "Protective role of ellagitannins from Eucalyptus citriodora against ethanol-induced gastric ulcer in rats: impact on oxidative stress, inflammation and calcitonin-gene related peptide." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 22, Issue 1, pp. 5-15, (2015) (PubMed).
: "The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice." in: Drug discoveries & therapeutics, Vol. 8, Issue 1, pp. 25-32, (2014) (PubMed).
: "5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts." in: PLoS ONE, Vol. 9, Issue 9, pp. e107890, (2014) (PubMed).
: "Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet." in: BMC ophthalmology, Vol. 13, Issue 1, pp. 14, (2013) (PubMed).
: "Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 8, pp. 3132-43, (2013) (PubMed).
: "ALOX5 promoter genotype, asthma severity and LTC production by eosinophils." in: Allergy, Vol. 61, Issue 1, pp. 97-103, (2005) (PubMed).
Synonyms and alternative names related to ALOX5
arachidonate 5-lipoxygenase (ALOX5), arachidonate 5-lipoxygenase (Alox5), arachidonate 5-lipoxygenase a (alox5a), arachidonate 5-lipoxygenase (AFUA_4G02770), arachidonate 5-lipoxygenase (AOR_1_1362014), Arachidonate 5-lipoxygenase (lox5), 5-LO, 5-LOX, 5LO, 5LPG, 5LX, AI850497, F730011J02, LOG5, lox5, LOX5A, si:dkey-194n13.2Protein level used designations for ALOX5
- LOX-5
- arachidonic 5-lipoxygenase alpha-10 isoform
- arachidonic 5-lipoxygenase delta-10-13 isoform
- arachidonic 5-lipoxygenase delta-13 isoform
- arachidonic 5-lipoxygenase delta-p10 isoform
- arachidonic acid 5-lipoxygenase
- leukotriene A4 synthase
- 5-lipoxygenase
- 5 - Lipoxygenase
- 5-LO
- LOX2
- arachidonate 5-lipoxygenase
- Arachidonate 5-lipoxygenase
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