ALK Antibodies
(Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).[provided by RefSeq, Jan 2011].
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Featured ALK Categories
ALK Antibodies
High quality antibodies with extensive validation data.
Recommended ALK Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC (p), WB
Validations
- (2)
Cat. No.
ABIN6243477
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC (p)
Validations
- (1)
- (1)
Cat. No.
ABIN6243478
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC (p)
Validations
- (1)
- (1)
Cat. No.
ABIN6243476
Quantity
400 μL
Datasheet
Datasheet
Latest Publications for our ALK products
: "Anaplastic lymphoma kinase immunohistochemistry in lung adenocarcinomas: Evaluation of performance of standard manual method using D5F3 antibody." in: Indian journal of cancer, Vol. 54, Issue 1, pp. 209-213, (2018) (PubMed).: "Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma." in: Oncology letters, Vol. 15, Issue 6, pp. 9317-9326, (2018) (PubMed).
: "Worse disease-free, tumor-specific, and overall survival in surgically-resected lung adenocarcinoma patients with ALK rearrangement." in: Oncotarget, Vol. 8, Issue 49, pp. 86066-86081, (2017) (PubMed).
: "Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 116-25, (2016) (PubMed).
: "A novel, highly sensitive ALK antibody 1A4 facilitates effective screening for ALK rearrangements in lung adenocarcinomas by standard immunohistochemistry." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 10, Issue 4, pp. 713-6, (2015) (PubMed).
: "Inflammatory myofibroblastic tumour of the bladder in children: A review." in: Journal of pediatric urology, (2015) (PubMed).
: "Extraordinary response to crizotinib in a woman with squamous cell lung cancer after two courses of failed chemotherapy." in: BMC pulmonary medicine, Vol. 14, pp. 83, (2014) (PubMed).
: "Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms." in: Human molecular genetics, Vol. 19, Issue 18, pp. 3544-56, (2010) (PubMed).
: "Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1." in: Blood, Vol. 89, Issue 4, pp. 1394-404, (1997) (PubMed).
Synonyms and alternative names related to ALK
anaplastic lymphoma kinase (Alk), anaplastic lymphoma receptor tyrosine kinase (ALK), ALK receptor tyrosine kinase (ALK), ALK receptor tyrosine kinase (Alk), ALK, CD246, NBLST3, TcrzProtein level used designations for ALK
- ALK tyrosine kinase receptor
- anaplastic lymphoma kinase (Ki-1)
- CD246 antigen
- mutant anaplastic lymphoma kinase
- anaplastic lymphoma receptor tyrosine kinase
- anaplastic lymphoma kinase
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