ALDH2 Products
(Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))
Categories
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011].
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Featured ALDH2 Categories
ALDH2 Antibodies
High quality antibodies with extensive validation data.
ALDH2 ELISA Kits
Reliable ELISA kits for a wide range of species.
ALDH2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ALDH2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, FACS, ICC
Validations
- (2)
- (8)
Cat. No.
ABIN1724795
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (2)
- (9)
Cat. No.
ABIN3021779
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF, IHC (p), ICC
Validations
- (7)
Cat. No.
ABIN2855041
Quantity
100 μL
Datasheet
Datasheet
Recommended ALDH2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6953593
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6953594
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964702
Quantity
96 tests
Datasheet
Datasheet
Recommended ALDH2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN666745
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344826
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344828
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ALDH2 products
: "Protein Phosphatase 2A Improves Cardiac Functional Response to Ischemia and Sepsis." in: International journal of molecular sciences, Vol. 23, Issue 9, (2022) (PubMed).: "Imaging PARP with [18F]rucaparib in pancreatic cancer models." in: European journal of nuclear medicine and molecular imaging, Vol. 49, Issue 11, pp. 3668-3678, (2022) (PubMed).
: "Fenofibrate -a PPARα agonist- increases alcohol dehydrogenase levels in the liver: implications for its possible use as an ethanol-aversive drug." in: Adicciones, pp. 1226, (2019) (PubMed).
: "Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide." in: Clinical and experimental pharmacology & physiology, Vol. 44, Issue 5, pp. 595-601, (2017) (PubMed).
: "Comparative Proteomics Analysis Reveals L-Arginine Activates Ethanol Degradation Pathways in HepG2 Cells." in: Scientific reports, Vol. 6, pp. 23340, (2017) (PubMed).
: "Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid β-oxidation pathway in HepG2 cells." in: Amino acids, Vol. 48, Issue 5, pp. 1297-307, (2017) (PubMed).
: "Mitochondrial aldehyde dehydrogenase 2 protects gastric mucosa cells against DNA damage caused by oxidative stress." in: Free radical biology & medicine, Vol. 93, pp. 165-76, (2016) (PubMed).
: "A novel mechanism for endogenous formaldehyde elevation in SAMP8 mouse." in: Journal of Alzheimer's disease : JAD, Vol. 40, Issue 4, pp. 1039-53, (2014) (PubMed).
: "Laser microdissection and two-dimensional difference gel electrophoresis reveal the role of a novel macrophage-capping protein in lymph node metastasis in gastric cancer." in: Journal of proteome research, Vol. 12, Issue 8, pp. 3780-91, (2013) (PubMed).
: "Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease." in: European heart journal, Vol. 33, Issue 13, pp. 1606-14, (2012) (PubMed).
Synonyms and alternative names related to ALDH2
aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 (aldh2.1), aldehyde dehydrogenase 2 family (mitochondrial) L homeolog (aldh2.L), aldehyde dehydrogenase 2 family (mitochondrial) (aldh2), aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), aldehyde dehydrogenase 2 (aldh2), aldehyde dehydrogenase (RHA1_RS43090), aldehyde dehydrogenase (NAD(+)) (aldH2), hypothetical protein (OE_RS03015), aldehyde dehydrogenase (aldH2), aldehyde dehydrogenase 2 family (mitochondrial) (Aldh2), aldehyde dehydrogenase 2, mitochondrial (Aldh2), Ahd-5, Ahd5, aldh-e2, ALDH-E2, aldh2, aldh2a, aldhi, ALDHI, aldm, ALDM, MGC80785, rf2b, zgc:63786Protein level used designations for ALDH2
- aldehyde dehydrogenase 2
- aldehyde dehydrogenase 2 family (mitochondrial)
- aldehyde dehydrogenase 2 family (mitochondrial)a
- aldehyde dehydrogenase 2.1
- mitochondrial aldehyde dehydrogenase 2
- ALDH2B6
- mitochondrial aldehyde dehydrogenase RF2B
- aldehyde dehydrogenase
- aldehyde dehydrogenase (NAD(+))
- ALDH class 2
- ALDH-E2
- aldehyde dehydrogenase, mitochondrial
- aldehyde dehydrogenase, mitochondrial-like
- acetaldehyde dehydrogenase 2
- liver mitochondrial ALDH
- nucleus-encoded mitochondrial aldehyde dehydrogenase 2
- ALDH1
- aldehyde dehydrogenase 2, mitochondrial
- mitochondrial aldehyde dehydrogenase
- ALDHI
- AHD-M1
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