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AKR1C4 Products

(Aldo-keto Reductase Family 1 Member C4 (AKR1C4))

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This gene encodes a member of the aldo\\/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and\\/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008].

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Featured AKR1C4 Categories

AKR1C4 Antibodies

High quality antibodies with extensive validation data.

AKR1C4 ELISA Kits

Reliable ELISA kits for a wide range of species.

AKR1C4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended AKR1C4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (1)
  • (6)
Cat. No. ABIN560358
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (3)
Cat. No. ABIN514377
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (2)
Cat. No. ABIN514376
Quantity 50 μg
Datasheet Datasheet

Recommended AKR1C4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964709
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4881789
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6384210
Quantity 96 tests
Datasheet Datasheet

Recommended AKR1C4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7121778
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1344762
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN1095981
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our AKR1C4 products

Ebert, Kisiela, Wsól, Maser: "Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29." in: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 239-49, (2011) (PubMed).

Stayrook, Rogers, Savkur, Wang, Su, Varga, Bu, Wei, Nagpal, Liu, Burris: "Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha." in: Molecular pharmacology, Vol. 73, Issue 2, pp. 607-12, (2008) (PubMed).

Lord, Mack, Van Den Berg, Pike, Ingles, Haiman, Wang, Parisky, Hodis, Ursin: "Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study." in: Breast cancer research : BCR, Vol. 7, Issue 3, pp. R336-44, (2005) (PubMed).

Synonyms and alternative names related to AKR1C4

aldo-keto reductase family 1 member C4 (AKR1C4), 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA

Protein level used designations for AKR1C4

  • 3-alpha-HSD1
  • aldo-keto reductase family 1 member C4
  • chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4
  • dihydrodiol dehydrogenase isozyme DD4
  • type I 3-alpha-hydroxysteroid dehydrogenase
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