AKR1C21 Proteins
(Aldo-Keto Reductase Family 1, Member C21 (AKR1C21))
NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into epitestosterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha- hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3- ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17- alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids (By similarity).
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Recommended AKR1C21 Proteins
Synonyms and alternative names related to AKR1C21
aldo-keto reductase family 1, member C21 (Akr1c21), 9430025F20Rik, AI315367Protein level used designations for AKR1C21
- 17-alpha-HSD
- 17-alpha-hydroxysteroid dehydrogenase
- 3(17)alpha-hydroxysteroid dehydrogenase
- 3(or 17)-alpha-hydroxysteroid dehydrogenase
- 3-alpha-hydroxysteroid dehydrogenase
- DD1
- DD3
- aldo-keto reductase family 1 member C21
- dihydrodiol dehydrogenase type 1
- dihydrodiol dehydrogenase type 3
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