AKR1C2 Products
(Aldo-keto Reductase Family 1, Member C2 (AKR1C2))
Categories
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
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Featured AKR1C2 Categories
AKR1C2 Antibodies
High quality antibodies with extensive validation data.
AKR1C2 ELISA Kits
Reliable ELISA kits for a wide range of species.
AKR1C2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended AKR1C2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN7265549
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, StM
Validations
- (5)
Cat. No.
ABIN6939232
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (3)
Cat. No.
ABIN560582
Quantity
50 μL
Datasheet
Datasheet
Recommended AKR1C2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6953599
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5653669
Quantity
96 tests
Datasheet
Datasheet
Recommended AKR1C2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121783
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344758
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344756
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our AKR1C2 products
: "Aldo-keto reductase and sorbitol dehydrogenase enzymes in Egyptian diabetic patients with and without proliferative diabetic retinopathy." in: Clinical & experimental optometry, Vol. 96, Issue 3, pp. 303-9, (2013) (PubMed).: "Proteomics-based identification of secreted protein dihydrodiol dehydrogenase 2 as a potential biomarker for predicting cisplatin efficacy in advanced NSCLC patients." in: Lung cancer (Amsterdam, Netherlands), Vol. 77, Issue 2, pp. 427-32, (2012) (PubMed).
: "Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29." in: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 239-49, (2011) (PubMed).
: "Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis." in: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 217-26, (2011) (PubMed).
: "Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 36, Issue 6, pp. 991-4, (2008) (PubMed).
: "Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis." in: Toxicology, Vol. 244, Issue 2-3, pp. 257-70, (2008) (PubMed).
Synonyms and alternative names related to AKR1C2
aldo-keto reductase family 1 member C2 (AKR1C2), aldo-keto reductase family 1, member C2 (Akr1c2), AKR1C-pseudo, Akr1c21, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8Protein level used designations for AKR1C2
- 3-alpha-HSD3
- DD-2
- DD/BABP
- aldo-keto reductase family 1 member C2
- chlordecone reductase homolog HAKRD
- dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III
- pseudo-chlordecone reductase
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- type II dihydrodiol dehydrogenase
- 17-alpha-HSD
- 17-alpha-hydroxysteroid dehydrogenase
- 3(or 17)-alpha-hydroxysteroid dehydrogenase
- 3-alpha-hydroxysteroid dehydrogenase
- aldo-keto reductase family 1 member C21
- aldo-keto reductase family 1, member C21
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