AKR1C1 Products
(Dihydrodiol Dehydrogenase (DDH))
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008].
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Featured AKR1C1 Categories
AKR1C1 Antibodies
High quality antibodies with extensive validation data.
AKR1C1 ELISA Kits
Reliable ELISA kits for a wide range of species.
AKR1C1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended AKR1C1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p), IF, ICC
Validations
- (3)
- (8)
Cat. No.
ABIN2856139
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (2)
Cat. No.
ABIN560581
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (3)
Cat. No.
ABIN514922
Quantity
100 μL
Datasheet
Datasheet
Recommended AKR1C1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966360
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4881783
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6385539
Quantity
96 tests
Datasheet
Datasheet
Recommended AKR1C1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122663
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344752
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344754
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our AKR1C1 products
: "The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer." in: Theranostics, Vol. 10, Issue 5, pp. 2188-2200, (2020) (PubMed).: "Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism." in: Frontiers in physiology, Vol. 10, pp. 833, (2019) (PubMed).
: "AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer." in: Theranostics, Vol. 8, Issue 3, pp. 676-692, (2018) (PubMed).
: "Cisplatin resistance in human cervical, ovarian and lung cancer cells." in: Cancer chemotherapy and pharmacology, Vol. 75, Issue 6, pp. 1217-27, (2015) (PubMed).
: "An endogenous inhibitor of angiogenesis inversely correlates with side population phenotype and function in human lung cancer cells." in: Oncogene, Vol. 33, Issue 9, pp. 1198-206, (2014) (PubMed).
: "The sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencing." in: PLoS ONE, Vol. 9, Issue 9, pp. e107158, (2014) (PubMed).
: "Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29." in: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 239-49, (2011) (PubMed).
: "Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells." in: Oncogene, Vol. 27, Issue 13, pp. 1916-29, (2008) (PubMed).
: "Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease." in: The European journal of neuroscience, Vol. 11, Issue 6, pp. 1988-94, (1999) (PubMed).
: "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting." in: The Journal of biological chemistry, Vol. 273, Issue 48, pp. 31633-6, (1998) (PubMed).
Synonyms and alternative names related to AKR1C1
aldo-keto reductase family 1 member C1 (AKR1C1), aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) (AKR1C1), 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBABProtein level used designations for AKR1C1
- 20 alpha-hydroxysteroid dehydrogenase
- 20-alpha-hydroxysteroid dehydrogenase
- aldo-keto reductase C
- aldo-keto reductase family 1 member C1
- chlordecone reductase homolog HAKRC
- dihydrodiol dehydrogenase 1
- dihydrodiol dehydrogenase 1/2
- dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase
- dihydrodiol dehydrogenase isoform DD1
- hepatic dihydrodiol dehydrogenase
- high-affinity hepatic bile acid-binding protein
- indanol dehydrogenase
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- type II 3-alpha-hydroxysteroid dehydrogenase
- 20-alpha-HSD
- aldo-keto reductase family 1 member C1 homolog
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