AGL Products
(Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL))
Categories
This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured AGL Categories
AGL Antibodies
High quality antibodies with extensive validation data.
AGL ELISA Kits
Reliable ELISA kits for a wide range of species.
AGL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended AGL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (6)
- (4)
Cat. No.
ABIN389030
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (10)
- (2)
Cat. No.
ABIN1882062
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN6243594
Quantity
400 μL
Datasheet
Datasheet
Recommended AGL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953680
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Sandwich ELISA
Validations
Cat. No.
ABIN418882
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Dog
Analytical Method
Validations
Cat. No.
ABIN2870202
Quantity
96 tests
Datasheet
Datasheet
Recommended AGL Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7422415
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7420006
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2714454
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our AGL products
: "Commentary on: "Enzalutamide monotherapy in hormone-naive prostate cancer: primary analysis of an open-label, single-arm, phase 2 study." Tombal B, Borre M, Rathenborg P, Werbrouck P, Van Poppel H, ..." in: Urologic oncology, (2015) (PubMed).: "Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice." in: The Journal of biological chemistry, (2015) (PubMed).
: "Loss of glycogen debranching enzyme AGL drives bladder tumor growth via induction of hyaluronic acid synthesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, (2015) (PubMed).
: "Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylase." in: Molecular neurobiology, Vol. 49, Issue 2, pp. 645-57, (2014) (PubMed).
: "Anti-retinal antibodies in patients with macular telangiectasia type 2." in: Investigative ophthalmology & visual science, Vol. 54, Issue 8, pp. 5675-83, (2013) (PubMed).
: "Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25372-81, (2010) (PubMed).
: "Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis." in: Muscle & nerve, Vol. 39, Issue 6, pp. 739-53, (2009) (PubMed).
: "Abnormal metabolism of glycogen phosphate as a cause for Lafora disease." in: The Journal of biological chemistry, Vol. 283, Issue 49, pp. 33816-25, (2008) (PubMed).
: "A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease." in: Genes & development, Vol. 21, Issue 19, pp. 2399-409, (2007) (PubMed).
: "Mutational and haplotype analysis of AGL in patients with glycogen storage disease type III." in: Journal of human genetics, Vol. 47, Issue 2, pp. 55-9, (2002) (PubMed).
Synonyms and alternative names related to AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (AGL), glycogen debranching enzyme (agl), glycogen debranching protein (MMAH_RS03870), amylo-1,6-glucosidase, 4-alpha-glucanotransferase (Agl), amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (Agl), 1110061O17Rik, 9430004C13Rik, 9630046L06Rik, AI850929, C77197, DDBDRAFT_0219237, DDBDRAFT_0234114, DDB_0219237, DDB_0234114, GDEProtein level used designations for AGL
- amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III)
- glycogen debranching enzyme
- amylo-1, 6-glucosidase, 4-alpha-glucanotransferase
- amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
- glycogen storage disease type III
- glycogen debrancher
- amylo-1,6-glucosidase, 4-alpha-glucanotransferase
- Glycogen debrancher
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