The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5\;11)(q31\;q31q23). [provided by RefSeq, Oct 2011].
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Stasevich, Hayashi-Takanaka, Sato, Maehara, Ohkawa, Sakata-Sogawa, Tokunaga, Nagase, Nozaki, McNally, Kimura: "Regulation of RNA polymerase II activation by histone acetylation in single living cells." in: Nature, Vol. 516, Issue 7530, pp. 272-5, (2014) (PubMed).
Synonyms and alternative names related to AFF4
AF4/FMR2 family member 4 L homeolog (aff4.L), AF4/FMR2 family member 4 (AFF4), AF4/FMR2 family, member 4 (aff4), AF4/FMR2 family, member 4 (Aff4), AF5Q31, AFF4, Alf4, Laf4l, MCEF, RA_m002_jsmFBA6Br