ADAMTS4 Products
(ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008].
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Featured ADAMTS4 Categories
ADAMTS4 Antibodies
High quality antibodies with extensive validation data.
ADAMTS4 ELISA Kits
Reliable ELISA kits for a wide range of species.
ADAMTS4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ADAMTS4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
IHC, IF
Validations
- (6)
Cat. No.
ABIN7072947
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (4)
Cat. No.
ABIN7142886
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (1)
- (3)
Cat. No.
ABIN391642
Quantity
400 μL
Datasheet
Datasheet
Recommended ADAMTS4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (8)
- (1)
Cat. No.
ABIN6953462
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6974698
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953463
Quantity
96 tests
Datasheet
Datasheet
Recommended ADAMTS4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305903
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305901
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7409560
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ADAMTS4 products
: "MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1β-Induced Catabolism in Human Articular Chondrocytes." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 44, Issue 1, pp. 38-52, (2018) (PubMed).: "AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice." in: Scientific reports, Vol. 7, pp. 43245, (2017) (PubMed).
: "VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts." in: Journal of cellular and molecular medicine, Vol. 20, Issue 4, pp. 678-87, (2016) (PubMed).
: "From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases." in: International wound journal, (2016) (PubMed).
: "Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs." in: Osteoarthritis and cartilage, Vol. 24, Issue 6, pp. 1103-12, (2016) (PubMed).
: "Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1β and Fibronectin and Contribution to ..." in: The American journal of pathology, Vol. 186, Issue 9, pp. 2449-61, (2016) (PubMed).
: "Protective effect of calcitonin on lumbar fusion-induced adjacent-segment disc degeneration in ovariectomized rat." in: BMC musculoskeletal disorders, Vol. 16, pp. 342, (2016) (PubMed).
: "A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes." in: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, (2015) (PubMed).
: "Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 23, Issue 11, pp. 2045-57, (2015) (PubMed).
: "Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases." in: Archives of pathology & laboratory medicine, Vol. 138, Issue 5, pp. 643-50, (2014) (PubMed).
Synonyms and alternative names related to ADAMTS4
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4), ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4), ADAM metallopeptidase with thrombospondin type 1 motif 4 (Adamts4), 3830423K05, ADAM-TS4, ADAMTS-2, ADAMTS-4, ADAMTS4, ADMP-1, mKIAA0688Protein level used designations for ADAMTS4
- A disintegrin and metalloproteinase with thrombospondin motifs 4
- ADAM-TS 4
- ADAMTS-4
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
- aggrecanase-1
- ADAM-TS4
- Aggrecanase
- a disintegrin and metallopeptidase with thrombospondin motifs 4
- a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
- ADMP-1
- ADAM metallopeptidase with thrombospondin type 1 motif, 4
- A disintegrin and metalloproteinase with thrombospondin motifs 4-like
- disintegrin and metalloproteinase with thrombospondin motifs 2
- a disintegrin and metalloproteinase with thrombospondin motifs 4
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