Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Kaliotoxin-1

Catalog No. ABIN1540091
  • Target
    Kaliotoxin-1
    Application
    Blocking Reagent (BR)
    Purpose
    Kaliotoxin-1 is a BK channel inhibitor
    Sequence
    Gly-Val-Glu-Ile-Asn-Val-Lys-Cys8-Ser-Gly-Ser-Pro-Gln-Cys14-Leu-Lys-Pro-Cys18-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn-Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OHDisulfid e bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35
  • Restrictions
    For Research Use only
  • Target
    Kaliotoxin-1
    Background
    Kaliotoxin-1 has been isolated from the venom of the Scorpion Androctonus mauretanicus mauretanicus. Kaliotoxin-1 is a potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). This toxin also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Kaliotoxin-1 induces atransient period of fast flickering in the channel openings, followed by an almost complete blockage of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than that of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.
    Molecular Weight
    4150.37 Da
You are here:
Support