Garcinol
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- Application
- Blocking Antibody (Inhibition)
- Characteristics
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Potent histone acetyltransferases inhibitor
Induces HeLa cell apoptosis
Anti-inflammatory and anti-carcinogenic
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- Restrictions
- For Research Use only
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- Storage
- 4 °C
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- Background
- Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF with IC50 of 7 and 5 uM, respectively. It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth. A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells. It induces apoptosis in several types of cancer cells and has anti-inflammatory actions.
- CAS-No
- 78824-30-3
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