Phenylbutyrate Na
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- Purpose
- HDAC inhibitor
- Characteristics
- Histone deacetylase inhibitor.
- Purity
- >98 %
- Chemical Name
- Sodium 4-phenylbutanoate, 4-PB
- Formula
- C10H11NaO2
- Solubility
- Soluble to 1100 mM in water and 100 mM in DMSO
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- Comment
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Source: Synthetic.
Appearance: White solid - Restrictions
- For Research Use only
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- Format
- Solid
- Precaution of Use
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- Handling Advice
- Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- Storage
- -20 °C
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- Background
- Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of gamma-globin gene.
- Molecular Weight
- 186.18
- CAS-No
- 1716-12-7
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