ACVR2B Products
(Activin A Receptor, Type IIB (ACVR2B))
Categories
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008].
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Featured ACVR2B Categories
ACVR2B Antibodies
High quality antibodies with extensive validation data.
ACVR2B ELISA Kits
Reliable ELISA kits for a wide range of species.
ACVR2B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ACVR2B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Sheep, Zebrafish (Danio rerio)
Application
WB
Validations
- (5)
Cat. No.
ABIN2782110
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (3)
Cat. No.
ABIN1714650
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (2)
Cat. No.
ABIN391162
Quantity
400 μL
Datasheet
Datasheet
Recommended ACVR2B ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953430
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4881730
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6385086
Quantity
96 tests
Datasheet
Datasheet
Recommended ACVR2B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305815
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305817
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7320385
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ACVR2B products
: "Modulation of noncanonical TGF-? signaling prevents cleft palate in Tgfbr2 mutant mice." in: The Journal of clinical investigation, Vol. 122, Issue 3, pp. 873-85, (2012) (PubMed).: "Myostatin is associated with age-related human muscle stem cell dysfunction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 6, pp. 2509-21, (2012) (PubMed).
: "Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation." in: Developmental biology, Vol. 266, Issue 2, pp. 334-45, (2004) (PubMed).
: "An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28036-44, (2004) (PubMed).
: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." in: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, (2003) (PubMed).
Synonyms and alternative names related to ACVR2B
activin A receptor type 2B (ACVR2B), activin A receptor type 2B (acvr2b), activin A receptor type 2B L homeolog (acvr2b.L), activin A receptor type 2B (Acvr2b), activin A receptor type 2Ba (acvr2ba), activin receptor IIB (Acvr2b), actr-iib, ActR-IIB, actr2b, actriib, ACTRIIB, ActRIIB, actrIIb, ACVR2B, HTX4, wu:fj97d11, XAR1Protein level used designations for ACVR2B
- activin A receptor, type IIB
- activin receptor type IIB
- activin receptor type-2B-like
- activin type IIB receptor
- activin receptor type-2B
- ACTR-IIB
- testicular activin receptor IIB
- ActRIIB type II activin receptor B
- Activine receptor 2b (transmembrane serine kinase)
- activin receptor IIB
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