ACTH Products
(Adrenocorticotropic hormone (ACTH))
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This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
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Featured ACTH Categories
ACTH Antibodies
High quality antibodies with extensive validation data.
ACTH ELISA Kits
Reliable ELISA kits for a wide range of species.
ACTH Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ACTH Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, ELISA, ICC
Validations
- (6)
Cat. No.
ABIN7193645
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS, ELISA
Validations
- (4)
Cat. No.
ABIN7193599
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN668661
Quantity
100 μL
Datasheet
Datasheet
Recommended ACTH ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6963593
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6953539
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Competition ELISA
Validations
- (9)
- (1)
Cat. No.
ABIN6953541
Quantity
96 tests
Datasheet
Datasheet
Recommended ACTH Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505394
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2746199
Quantity
5 applications
Datasheet
Datasheet
Latest Publications for our ACTH products
: "Reprogramming of glucocorticoid receptor function by hypoxia. ..." in: EMBO reports, Vol. 23, Issue 1, pp. e53083, (2022) (PubMed).: "Repeated unpredictable stress and social isolation induce chronic HPA axis dysfunction and persistent abnormal fear memory." in: Progress in neuro-psychopharmacology & biological psychiatry, Vol. 104, pp. 110035, (2021) (PubMed).
: "ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation. ..." in: iScience, Vol. 24, Issue 7, pp. 102790, (2021) (PubMed).
: "Chemokine CXCL14-like immunoreactivity in the αMSH-producing cells and PRL-producing cells of the flat-tailed house gecko pituitary." in: The Journal of veterinary medical science, Vol. 82, Issue 4, pp. 408-413, (2020) (PubMed).
: "Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition." in: Scientific reports, Vol. 9, Issue 1, pp. 6456, (2020) (PubMed).
: "Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol." in: Alcoholism, clinical and experimental research, Vol. 43, Issue 9, pp. 1887-1897, (2020) (PubMed).
: "Hypothalamus-pituitary-adrenal axis imbalance and inflammation contribute to sex differences in separation- and restraint-induced depression." in: Hormones and behavior, Vol. 122, pp. 104741, (2020) (PubMed).
: "Anxiolytic and Anti-depressive Like Effects of Translocator Protein (18 kDa) Ligand YL-IPA08 in a Rat Model of Postpartum Depression." in: Neurochemical research, Vol. 45, Issue 8, pp. 1746-1757, (2020) (PubMed).
: "Altered glucocorticoid metabolism represents a feature of macroph-aging." in: Aging cell, Vol. 19, Issue 6, pp. e13156, (2020) (PubMed).
: "Long term transcriptional and behavioral effects in mice developmentally exposed to a mixture of endocrine disruptors associated with delayed human neurodevelopment." in: Scientific reports, Vol. 10, Issue 1, pp. 9367, (2020) (PubMed).
Synonyms and alternative names related to ACTH
pro-opiomelanocortin-alpha (Pomc), proopiomelanocortin (POMC), ACTH, alpha-MSH, alphaMSH, BE, Beta-LPH, beta-MSH, Clip, CLIP, Gamma-LPH, gamma-MSH, LPH, MSH, Npp, NPP, POC, Pomc-1, Pomc1Protein level used designations for ACTH
- adrenal corticotropic hormone
- adrenocorticotropic hormone
- alpha-melanocyte stimulating hormone
- beta-endorphin
- corticotropin-like intermediary peptide
- corticotropin-lipotropin
- melanotropin gamma
- met-enkephalin
- pro-opiomelanocortin
- adrenocorticotropin
- alpha-MSH
- alpha-melanocyte-stimulating hormone
- beta-LPH
- beta-MSH
- beta-melanocyte-stimulating hormone
- gamma-LPH
- gamma-MSH
- lipotropin beta
- lipotropin gamma
- melanotropin alpha
- melanotropin beta
- opiomelanocortin prepropeptide
- pro-ACTH-endorphin
- proopiomelanocortin preproprotein
- proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
- beta-lipotropin
- beta-melanocyte stimulating hormone
Did you look for something else?
- ACTG2
- ACTBL3
- ACTBL2
- ACTA1/ACTA2A/ACTG2
- ACSS3
- ACSS2
- ACSS1
- ACSM5
- ACSM4
- ACSM3
- ACSM2A
- ACSM2
- ACSM1
- ACSL6
- ACSL5
- ACSL4
- Acsl3
- ACSF3
- ACSF2
- ACSF
- Actin
- Actin Binding LIM Protein 1
- Actin Filament Associated Protein 1-Like 1
- Actin Related Protein 2/3 Complex, Subunit 5-Like
- Actin Related Protein 2/3 Complex, Subunit 5, 16kDa
- Actin-Like 6A
- Actin-Like 6B
- Actin-Like 7A
- Actin-Like 8
- Actin-Related Protein 2
- Actin, alpha 1, Skeletal Muscle
- Actin, alpha 2, Smooth Muscle, Aorta
- Actin, Alpha, Cardiac Muscle 1
- Actin, Alpha, gamma
- Actin, beta 2
- Actin, Beta, gamma
- Actin, gamma 1
- Actin, Muscle Specific
- Activated Leukocyte Cell Adhesion Molecule
- Activated Protein C
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