ACPP Products
(Acid Phosphatase, Prostate (ACPP))
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This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
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Featured ACPP Categories
ACPP Antibodies
High quality antibodies with extensive validation data.
ACPP ELISA Kits
Reliable ELISA kits for a wide range of species.
ACPP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ACPP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (9)
Cat. No.
ABIN7431248
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7438529
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN3022672
Quantity
100 μL
Datasheet
Datasheet
Recommended ACPP ELISA Kits
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Reactivity
Analytical Method
Validations
Cat. No.
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Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964540
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953397
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative
Validations
Cat. No.
ABIN777999
Quantity
96 tests
Datasheet
Datasheet
Recommended ACPP Proteins
Latest Publications for our ACPP products
: "Pharmacological targeting of plasmin prevents lethality in a murine model of macrophage activation syndrome." in: Blood, Vol. 130, Issue 1, pp. 59-72, (2017) (PubMed).: "Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases." in: Endocrinology, Vol. 157, Issue 12, pp. 4526-4533, (2016) (PubMed).
: "Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations." in: PLoS ONE, Vol. 9, Issue 5, pp. e97851, (2014) (PubMed).
: "Evaluation of protein biomarkers of prostate cancer aggressiveness." in: BMC cancer, Vol. 14, pp. 244, (2014) (PubMed).
: "An evolutionarily conserved mode of modulation of Shaw-like K? channels." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 4, pp. 1381-93, (2013) (PubMed).
: "Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model." in: Proteome science, Vol. 9, pp. 73, (2011) (PubMed).
: "Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 27, Issue 11, pp. 1788-93, (2009) (PubMed).
: "Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease." in: Journal of proteomics, Vol. 72, Issue 6, pp. 907-17, (2009) (PubMed).
: "Identification of HLA-DRB1*1501-restricted T-cell epitopes from human prostatic acid phosphatase." in: The Prostate, Vol. 67, Issue 10, pp. 1019-28, (2007) (PubMed).
: "Prostatic acid phosphatase is not a prostate specific target." in: Cancer research, Vol. 67, Issue 14, pp. 6549-54, (2007) (PubMed).
Synonyms and alternative names related to ACPP
acid phosphatase, prostate (ACPP), ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2), acid phosphatase, prostate (Acpp), prostatic acid phosphatase (CpipJ_CPIJ004002), prostatic acid phosphatase, putative (Smp_016640), acid phosphatase, prostate S homeolog (acpp.S), 5'-NT, A030005E02Rik, ACP-3, acp-3, ACP3, acp3, ACPP, Acpp11, acpt, AMAP2, CENTB3, DDEF2, FRAP, Lap, PAG3, PAP, pap, Pap-alpha, Ppal, RNACPP11, SHAG1Protein level used designations for ACPP
- 5'-nucleotidase
- TMPase
- ecto-5'-nucleotidase
- prostatic acid phosphatase
- prostatic acid phosphotase
- thiamine monophosphatase
- PYK2 C terminus-associated protein
- arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
- centaurin, beta 3
- development and differentiation enhancing factor 2
- development and differentiation-enhancing factor 2
- paxillin-associated protein with ARF GAP activity 3
- pyk2 C-terminus-associated protein
- fluoride-resistant acid phosphatase
- lysosomal acid phosphatase
- prostatic acid phosphatase (rPAP)
- acid phosphatase, prostate
- tyrosine acid phosphatase
- prostatic acid phosphatase-like
- testicular acid phosphatase homolog
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