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Aconitase 1 Products

(Aconitase 1 (ACO1))

Categories

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq, Jul 2008].

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Featured Aconitase 1 Categories

Aconitase 1 Antibodies

High quality antibodies with extensive validation data.

Aconitase 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Aconitase 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Aconitase 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
  • (9)
Cat. No. ABIN7438541
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7445504
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application WB, IHC
Validations
  • (8)
Cat. No. ABIN2778793
Quantity 100 μL
Datasheet Datasheet

Recommended Aconitase 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
Cat. No. ABIN6720599
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6953399
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1120137
Quantity 96 tests
Datasheet Datasheet

Recommended Aconitase 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1305652
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1305650
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7279292
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Aconitase 1 products

Deng, Manz, Torti, Torti: "Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth." in: Oncotarget, Vol. 8, Issue 47, pp. 82231-82243, (2017) (PubMed).

Rupani, Connell: "Transferrin receptor mRNA interactions contributing to iron homeostasis." in: RNA (New York, N.Y.), Vol. 22, Issue 8, pp. 1271-82, (2016) (PubMed).

Rurek, Woyda-Ploszczyca, Jarmuszkiewicz et al.: "Biogenesis of mitochondria in cauliflower (Brassica oleracea var. botrytis) curds subjected to temperature stress and recovery involves regulation of the complexome, respiratory chain activity, ..." in: Biochimica et biophysica acta, Vol. 1847, Issue 4-5, pp. 399-417, (2015) (PubMed).

Dongiovanni, Lanti, Gatti, Rametta, Recalcati, Maggioni, Fracanzani, Riso, Cairo, Fargion, Valenti: "High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload." in: PLoS ONE, Vol. 10, Issue 2, pp. e0116855, (2015) (PubMed).

Haro, Sheth, Scheinberg: "Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells." in: PLoS ONE, Vol. 7, Issue 11, pp. e48841, (2012) (PubMed).

Reuter, Reiermann, Wörner, Schröter, Edemir, Buck, Henning, Peter-Katalinic, Vollenbröker, Amann, Pavenstädt, Schlatter, Gabriëls: "IF/TA-related metabolic changes--proteome analysis of rat renal allografts." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 25, Issue 8, pp. 2492-501, (2010) (PubMed).

Wang, Di, DAgostino, Torti, Torti: "Excess capacity of the iron regulatory protein system." in: The Journal of biological chemistry, Vol. 282, Issue 34, pp. 24650-9, (2007) (PubMed).

Synonyms and alternative names related to Aconitase 1

aconitase 1 (ACO1), aconitase 1 (Aco1), aconitase 1, soluble (ACO1), aconitase 1 L homeolog (aco1.L), Aco-1, Aco1, Acon1, ACONS, AI256519, IREB1, IREBP, Irebp, IREBP1, IRP1, Irp1, Ratireb, ratireb

Protein level used designations for Aconitase 1

  • IRE-BP 1
  • aconitate hydratase, cytoplasmic
  • citrate hydro-lyase
  • cytoplasmic aconitate hydratase
  • ferritin repressor protein
  • iron regulatory protein 1
  • iron-responsive element binding protein 1
  • iron-responsive element-binding protein 1
  • IRP1
  • IRE-binding protein 1
  • Iron responsive element binding protein
  • aconitase
  • cytoplasmic aconitase
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