ACLY Products
(ATP Citrate Lyase (ACLY))
Categories
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
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Featured ACLY Categories
ACLY Antibodies
High quality antibodies with extensive validation data.
ACLY ELISA Kits
Reliable ELISA kits for a wide range of species.
ACLY Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ACLY Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (2)
- (7)
Cat. No.
ABIN1098143
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN7265716
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (5)
Cat. No.
ABIN6136002
Quantity
100 μL
Datasheet
Datasheet
Recommended ACLY ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965053
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965052
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965051
Quantity
96 tests
Datasheet
Datasheet
Recommended ACLY Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121924
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
Cat. No.
ABIN7194322
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3088222
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ACLY products
: "mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer." in: Oncotarget, Vol. 7, Issue 18, pp. 25224-40, (2018) (PubMed).: "The contribution of the citrate pathway to oxidative stress in Down syndrome." in: Immunology, Vol. 149, Issue 4, pp. 423-431, (2016) (PubMed).
: "Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells." in: International journal of cancer, Vol. 135, Issue 1, pp. 37-47, (2014) (PubMed).
: "Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth." in: Cancer letters, Vol. 349, Issue 1, pp. 15-25, (2014) (PubMed).
: "ATP-citrate lyase is essential for macrophage inflammatory response." in: Biochemical and biophysical research communications, Vol. 440, Issue 1, pp. 105-11, (2013) (PubMed).
: "ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 42, pp. 32606-15, (2010) (PubMed).
: "Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 10, pp. 2282-95, (2010) (PubMed).
Synonyms and alternative names related to ACLY
ATP citrate lyase (ACLY), ATP citrate lyase S homeolog (acly.S), ATP-citrate synthase (LOC587157), ATP citrate lyase (acly), ATP citrate lyase (ATPCL), ATP-citrate synthase (LOC5564509), citrate synthase, mitochondrial (CpipJ_CPIJ010291), ATP-citrate synthase (Bm1_26245), atp-citrate synthase (ACL), ATP citrate lyase (Acly), ATP citrate lyase a (aclya), A730098H14Rik, ACL, ACLY, acly, anon-WO0140519.179, ATPCL, AW538652, BcDNA:LD21334, cb722, CG8322, CLATP, Clatp, dATPCL, DDBDRAFT_0205389, DDBDRAFT_0235360, DDB_0205389, DDB_0235360, DmATPCL, Dmel\\CG8322, l(2)01466, l(2)k09217, n(2)k09217, zgc:92008Protein level used designations for ACLY
- ATP citrate lyase
- ATP citrate synthase
- ATP-citrate synthase-like
- ATP-citrate lyase
- ATPCL-PD
- ATPCL-PE
- ATPCL-PF
- CG8322-PD
- CG8322-PE
- CG8322-PF
- ATP-citrate synthase
- citrate synthase, mitochondrial
- atp-citrate synthase
- ATP-citrate (pro-S-)-lyase
- citrate cleavage enzyme
Did you look for something else?
- ACIN1
- Acid Phosphatase
- Acid Invertase
- AChR Ab
- ACHB3
- Achaete-scute complex protein T5
- Achaete-Scute Complex Homolog 1 (Drosophila)
- Achaete
- Acetylcholinesterase
- Acetylcholine
- Acetylated Lysine
- Acetyl-CoA Carboxylase beta
- Acetyl-CoA Carboxylase alpha
- Acetyl-CoA Carboxylase
- Acetyl-CoA
- Acetoin Reductase
- Acetate Kinase
- ACER3
- ACER2
- ACER1
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