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ACE2 Products

(Angiotensin I Converting Enzyme 2 (ACE2))

Categories

ACE2 short description:

Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042, PubMed:10924499, PubMed:11815627, PubMed:19021774, PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582).

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Featured ACE2 Categories

ACE2 Antibodies

High quality antibodies with extensive validation data.

ACE2 ELISA Kits

Reliable ELISA kits for a wide range of species.

ACE2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ACE2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (4)
  • (5)
Cat. No. ABIN1169449
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro)
Validations
  • (1)
  • (5)
Cat. No. ABIN730798
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN6136429
Quantity 100 μL
Datasheet Datasheet

Recommended ACE2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6963302
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6953749
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964862
Quantity 96 tests
Datasheet Datasheet

Recommended ACE2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (7)
Cat. No. ABIN6952431
Quantity 200 μg
Datasheet Datasheet
Reactivity Paguma larvata
Source HEK-293 Cells
Validations
  • (8)
Cat. No. ABIN6952704
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7273792
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our ACE2 products

Chaouat, Achdout, Kol, Berhani, Roi, Vitner, Melamed, Politi, Zahavy, Brizic, Lenac Rovis, Alfi, Wolf, Jonjic, Israely, Mandelboim: "SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection." in: PLoS pathogens, Vol. 17, Issue 12, pp. e1010175, (2022) (PubMed).

Chaouat, Brizic, Kucan Brlic, Atari, Kliker, Alfi, Mandelboim, Wolf, Tafish, Kol, Jonjic, Mandelboim: "Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern." in: iScience, Vol. 25, Issue 9, pp. 104935, (2022) (PubMed).

Wei, Alfajaro, DeWeirdt, Hanna, Lu-Culligan, Cai, Strine, Zhang, Graziano, Schmitz, Chen, Mankowski, Filler, Ravindra, Gasque, de Miguel, Patil, Chen, Oguntuyo, Abriola, Surovtseva, Orchard, Lee et al.: "Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection. ..." in: Cell, Vol. 184, Issue 1, pp. 76-91.e13, (2021) (PubMed).

Huang, Zhou, He, Chiem, Mabrouk, Nissly, Bird, Strauss, Sambhara, Ortega, Wohlfert, Martinez-Sobrido, Kuchipudi, Davidson, Lovell: "SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination." in: Advanced materials (Deerfield Beach, Fla.), Vol. 32, Issue 50, pp. e2005637, (2021) (PubMed).

Dogan, Kozhaya, Placek, Gunter, Yigit, Hardy, Plassmeyer, Coatney, Lillard, Bukhari, Kleinberg, Hayes, Arditi, Klapper, Merin, Liang, Gupta, Alpan, Unutmaz: "SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus." in: Communications biology, Vol. 4, Issue 1, pp. 129, (2021) (PubMed).

Chouchane, Grivel, Farag, Pavlovski, Maacha, Sathappan, Al-Romaihi, Abuaqel, Ata, Ismail Chouchane, Remadi, Halabi, Rafii, Al-Thani, Marr, Subramanian, Shan: "Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2." in: JCI insight, (2021) (PubMed).

Ozono, Zhang, Ode, Sano, Tan, Imai, Miyoshi, Kishigami, Ueno, Iwatani, Suzuki, Tokunaga: "SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity." in: Nature communications, Vol. 12, Issue 1, pp. 848, (2021) (PubMed).

Sharma, Gaikwad: "Ameliorative effect of AT2R and ACE2 activation on ischemic renal injury associated cardiac and hepatic dysfunction." in: Environmental toxicology and pharmacology, Vol. 80, pp. 103501, (2021) (PubMed).

Wei, Duan, Liu, Wang, Ding, Chen, Xie, Tian, Yu, Ge, Zhang, Chen, Li, Meng: "Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2." in: International immunopharmacology, Vol. 90, pp. 107172, (2021) (PubMed).

Bell, Powell, Rodriguez, Cochran, Kim: "Neutralizing antibodies targeting the SARS-CoV-2 receptor binding domain isolated from a naïve human antibody library." in: Protein science : a publication of the Protein Society, Vol. 30, Issue 4, pp. 716-727, (2021) (PubMed).

Synonyms and alternative names related to ACE2

angiotensin I converting enzyme (ACE), angiotensin I converting enzyme 2 (ACE2), angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), angiotensin I converting enzyme 2 (Ace2), angiotensin I converting enzyme 2 (ace2), angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), 2010305L05Rik, ACE1, ACEH, CD143, DCP, DCP1, ICH, MVCD3, zgc:92514

Protein level used designations for ACE2

  • CD143 antigen
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
  • angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript
  • angiotensin converting enzyme, somatic isoform
  • angiotensin-converting enzyme
  • carboxycathepsin
  • dipeptidyl carboxypeptidase 1
  • dipeptidyl carboxypeptidase I
  • kininase II
  • peptidase P
  • testicular ECA
  • ACE-related carboxypeptidase
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
  • angiotensin-converting enzyme 2
  • angiotensin-converting enzyme homolog
  • metalloprotease MPROT15
  • peptidyl-dipeptidase A
  • angiotensin I converting enzyme 2
  • anigotensin-converting enzyme-related carboxypeptidase
  • renal angiotensin-converting enzyme 2
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