ABI1 Products
(Abl-Interactor 1 (ABI1))
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This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10\;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011].
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Featured ABI1 Categories
ABI1 Antibodies
High quality antibodies with extensive validation data.
ABI1 ELISA Kits
Reliable ELISA kits for a wide range of species.
ABI1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ABI1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (11)
Cat. No.
ABIN7436735
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (6)
Cat. No.
ABIN7265359
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF, FACS
Validations
- (4)
Cat. No.
ABIN652475
Quantity
400 μL
Datasheet
Datasheet
Recommended ABI1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953383
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5651333
Quantity
96 tests
Datasheet
Datasheet
Recommended ABI1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305528
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7399865
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2714282
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our ABI1 products
: "Long-Term Exposure to Imatinib Mesylate Downregulates Hippo Pathway and Activates YAP in a Model of Chronic Myelogenous Leukemia." in: Stem cells and development, Vol. 26, Issue 9, pp. 656-677, (2017) (PubMed).: "AlphaII-spectrin participates in the surface expression of cell adhesion molecule L1 and neurite outgrowth." in: Experimental cell research, Vol. 322, Issue 2, pp. 365-80, (2014) (PubMed).
: "Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development." in: Developmental biology, Vol. 353, Issue 2, pp. 331-43, (2011) (PubMed).
: "Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma." in: Medical oncology (Northwood, London, England), Vol. 27, Issue 3, pp. 632-9, (2010) (PubMed).
: "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase." in: The Journal of biological chemistry, Vol. 278, Issue 24, pp. 21685-92, (2003) (PubMed).
: "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease." in: Gene, Vol. 271, Issue 2, pp. 159-69, (2001) (PubMed).
: "Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases." in: Molecular and cellular biology, Vol. 20, Issue 20, pp. 7591-601, (2000) (PubMed).
: "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton." in: The Journal of biological chemistry, Vol. 273, Issue 22, pp. 13681-92, (1998) (PubMed).
: "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)." in: Blood, Vol. 92, Issue 4, pp. 1125-30, (1998) (PubMed).
: "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth." in: Oncogene, Vol. 14, Issue 2, pp. 233-41, (1997) (PubMed).
Synonyms and alternative names related to ABI1
abl interactor 1 (ABI1), abl-interactor 1 (Abi1), abl-interactor 1a (abi1a), abl interactor 1 S homeolog (abi1.S), abl interactor 1 (abi1), abl-interactor 1b (abi1b), Abl-interactor 1 (Bm1_44660), Abl interactor 1 (abi1), abl-interactor 1 (LOAG_04356), abl interactor 1 (Abi1), ABI-1, abi-1, abi1, ABI1, ABLBP4, DKFZp469P1319, E3B1, E3b1, e3b1, MGC84356, NAP1, NAP1BP, nap1bp, SSH3BP, ssh3bp, SSH3BP1, Ssh3bp1, ssh3bp1, wu:fc66g09, wu:fe48a10, wu:fk56a10, zgc:73174, zgc:153534Protein level used designations for ABI1
- Abelson interactor 1
- Abl-interactor protein 1 long
- abl interactor 1
- abl-binding protein 4
- eps8 SH3 domain-binding protein
- interactor protein AblBP4
- nap1 binding protein
- spectrin SH3 domain-binding protein 1
- abelson interactor 1
- abi-1
- ablphilin-1
- eps8 binding protein
- eps8-binding protein
- spectrin SH3 domain binding protein 1
- eps8 binding protein (e3B1), alternatively spliced
- abl-interactor 1
- Abl-interactor 1
- Abl interactor 1
- abl interactor 1-like
- LOW QUALITY PROTEIN: abl interactor 1
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