ABCG8 Products
(ATP-Binding Cassette, Sub-Family G (WHITE), Member 8 (ABCG8))
Categories
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008].
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Featured ABCG8 Categories
ABCG8 Antibodies
High quality antibodies with extensive validation data.
ABCG8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ABCG8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (5)
Cat. No.
ABIN3022643
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7144942
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN6259696
Quantity
100 μL
Datasheet
Datasheet
Recommended ABCG8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419505
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419508
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3129571
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ABCG8 products
: "Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice." in: Gastroenterology research and practice, Vol. 2020, pp. 1343969, (2020) (PubMed).: "Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function." in: Cell death & disease, Vol. 9, Issue 2, pp. 173, (2019) (PubMed).
: "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." in: The Korean journal of internal medicine, (2018) (PubMed).
: "On the regulatory importance of 27-hydroxycholesterol in mouse liver." in: The Journal of steroid biochemistry and molecular biology, (2016) (PubMed).
: "Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism." in: Biochimica et biophysica acta, Vol. 1861, Issue 9 Pt A, pp. 1132-41, (2016) (PubMed).
: "Identification of the Functions of Liver X Receptor-β in Sertoli Cells Using a Targeted Expression-Rescue Model." in: Endocrinology, Vol. 156, Issue 12, pp. 4545-57, (2015) (PubMed).
: "Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice." in: Journal of lipid research, Vol. 55, Issue 3, pp. 540-8, (2014) (PubMed).
: "Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter." in: Scientific reports, Vol. 4, pp. 4258, (2014) (PubMed).
: "Lactobacillus acidophilus ATCC 4356 prevents atherosclerosis via inhibition of intestinal cholesterol absorption in apolipoprotein E-knockout mice." in: Applied and environmental microbiology, Vol. 80, Issue 24, pp. 7496-504, (2014) (PubMed).
: "Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease." in: Digestive diseases and sciences, Vol. 59, Issue 12, pp. 2975-82, (2014) (PubMed).
Synonyms and alternative names related to ABCG8
ATP binding cassette subfamily G member 8 (ABCG8), ATP-binding cassette sub-family G member 8 (PTRG_02054), ABC transporter G family protein (abcG8), ATP-binding cassette, sub-family G (WHITE), member 8 (abcg8), ATP binding cassette subfamily G member 8 (Abcg8), 1300003C16Rik, AI114946, DDBDRAFT_0167690, DDBDRAFT_0191232, DDB_0167690, DDB_0191232, GBD4, sterolin-2, STSL, zgc:172358Protein level used designations for ABCG8
- ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2)
- sterolin 2
- ATP-binding cassette sub-family G member 8
- sterolin-2
- ATP-binding cassette, sub-family G (WHITE), member 8
- ATP-binding cassette sub-family G member 8-like
- ATP-binding cassette, subfamily G, member 8
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