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ABCE1 antibody

RLI1 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5708515
  • Target
    ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))
    Reactivity
    Human, Mouse, Rat
    Host
    Rabbit
    Clonality
    Polyclonal
    Application
    Western Blotting (WB)
    Purification
    Antigen affinity purified
    Immunogen
    Amino acids K419-D599 from the human protein were used as the immunogen for the ABCE1 antibody.
    Isotype
    IgG
  • Application Notes
    Western blot: 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the ABCE1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))
    Alternative Name
    ABCE1 / ATP binding cassette E1
    Synonyms
    ATRLI1 antibody, RNAse l inhibitor protein 1 antibody, RNAse l inhibitor protein 1 antibody, ABCE1 antibody
    Background
    ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.
    UniProt
    P61221
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