ABCC2 Products
(ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2))
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008].
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Featured ABCC2 Categories
ABCC2 Antibodies
High quality antibodies with extensive validation data.
ABCC2 ELISA Kits
Reliable ELISA kits for a wide range of species.
ABCC2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ABCC2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7441076
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p)
Validations
- (3)
Cat. No.
ABIN737541
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
Cat. No.
ABIN514490
Quantity
100 μg
Datasheet
Datasheet
Recommended ABCC2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953980
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5652070
Quantity
96 tests
Datasheet
Datasheet
Recommended ABCC2 Proteins
Latest Publications for our ABCC2 products
: "Stimulatory effect of CSE-generated H2S on hepatic mitochondrial biogenesis and the underlying mechanisms." in: Nitric oxide : biology and chemistry, Vol. 58, pp. 67-76, (2016) (PubMed).: "Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes." in: Biomaterials, Vol. 34, Issue 18, pp. 4452-65, (2013) (PubMed).
: "Expression in human endothelial cells of ADP-ribosylation factors, 20-kDa guanine nucleotide-binding proteins involved in the initiation of vesicular transport." in: Journal of molecular and cellular cardiology, Vol. 28, Issue 9, pp. 1911-20, (1997) (PubMed).
: "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 23, pp. 12856-60, (1996) (PubMed).
: "Phospholipase D: a downstream effector of ARF in granulocytes." in: Science (New York, N.Y.), Vol. 263, Issue 5146, pp. 523-6, (1994) (PubMed).
: "ADP-ribosylation factors, 20,000 M(r) guanine nucleotide-binding protein activators of cholera toxin and components of intracellular vesicular transport systems." in: Cellular signalling, Vol. 5, Issue 4, pp. 367-79, (1993) (PubMed).
: "Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin." in: The Journal of biological chemistry, Vol. 259, Issue 10, pp. 6228-34, (1984) (PubMed).
Synonyms and alternative names related to ABCC2
ATP binding cassette subfamily C member 2 (ABCC2), ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (Abcc2), ATP binding cassette subfamily C member 2 (Abcc2), ABC30, Abc30, AI173996, CMOAT, Cmoat, cMRP, DJS, MRP2, Mrp2Protein level used designations for ABCC2
- ATP-binding cassette sub-family C member 2
- canalicular multidrug resistance protein
- canalicular multispecific organic anion transporter 1
- multidrug resistance-associated protein 2
- multidrug resistance protein 2
- ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- calicular multispecific organic anion transporter
- multidrug resistance associated protein 2
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