ABCA1 Products
(ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1))
Categories
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008].
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Featured ABCA1 Categories
ABCA1 Antibodies
High quality antibodies with extensive validation data.
ABCA1 ELISA Kits
Reliable ELISA kits for a wide range of species.
ABCA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ABCA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7433312
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7433309
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN1099759
Quantity
50 μL
Datasheet
Datasheet
Recommended ABCA1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6953966
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965059
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965058
Quantity
96 tests
Datasheet
Datasheet
Recommended ABCA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305421
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7393556
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7424299
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ABCA1 products
: "Macrophage iron retention aggravates atherosclerosis: Evidence for the role of autocrine formation of hepcidin in plaque macrophages." in: Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol. 1865, Issue 2, pp. 158531, (2020) (PubMed).: "Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression." in: Journal of pharmacological sciences, Vol. 142, Issue 1, pp. 9-15, (2020) (PubMed).
: "Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress." in: Cancer research, Vol. 80, Issue 2, pp. 189-203, (2020) (PubMed).
: "Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages." in: Frontiers in immunology, Vol. 9, pp. 135, (2019) (PubMed).
: "Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux." in: Oncogene, Vol. 38, Issue 12, pp. 2135-2150, (2019) (PubMed).
: "OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice." in: Biochimica et biophysica acta. Molecular basis of disease, Vol. 1865, Issue 1, pp. 161-180, (2019) (PubMed).
: "Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages." in: Molecular nutrition & food research, Vol. 63, Issue 2, pp. e1800713, (2019) (PubMed).
: "Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages." in: Molecular and cellular biology, Vol. 39, Issue 5, (2019) (PubMed).
: "Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages." in: Journal of lipid research, Vol. 60, Issue 3, pp. 506-515, (2019) (PubMed).
: "E3317 promotes cholesterol efflux in macrophage cells via enhancing ABCA1 expression." in: Biochemical and biophysical research communications, Vol. 504, Issue 1, pp. 68-74, (2019) (PubMed).
Synonyms and alternative names related to ABCA1
ATP binding cassette subfamily A member 1 (ABCA1), ATP binding cassette subfamily A member 1 (Abca1), ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1), ATP binding cassette subfamily A member 1 (abca1), ATP-binding cassette, sub-family A (ABC1), member 1 (Abca1), ATP-binding cassette A1 (ABCA1), ATP-binding cassette, sub-family A (ABC1), member 1B (abca1b), ABC-1, ABC1, Abc1, ABCA1, Arabidopsis thaliana ATP-binding cassette A1, AtABCA1, ATP-binding cassette A1, CERP, HDLDT1, im:7136239, sb:cb407, TGD, wu:fa07e06, zgc:171581Protein level used designations for ABCA1
- ATP-binding cassette sub-family A member 1
- ATP-binding cassette transporter A1
- cholesterol efflux regulatory protein
- membrane-bound
- ATP-binding cassette, sub-family A (ABC1), member 1
- ATP-binding cassette, sub-family A member 1
- ATP-binding cassette transporter 1
- Cholesterol efflux regulatory protein
- ATP-binding cassette transporter
- ATP-binding cassette, sub-family A member 1-like
- ATP-binding cassette sub-family A member 1-like
- ATP-binding cassette 1
- ATP-binding cassette, sub-family A (ABC1), member 1B
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