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News

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

The host protein calprotectin has now been identified as a neutrophil-dependent factor expressed inside Staphylococcus aureus abscesses by scientists from the Vanderbilt University (USA). Calprotectin derived from neutrophils inhibited growth of S. aureus by chelation of the nutrients Mn2+ and Zn2+. This reaction reprograms the bacterial trancriptome.  » Read more
07.05.2008  |  Anna Lena Marwedel      RSS Feed  New Antibodies

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

Areas: Blood, Virology
The feline leukaemia virus subgroup C receptor (FLVCR) exports cytoplasmic heme. A lab group from the University of Washington in Seattle (USA) now demonstrates how FLVCR-null mice lack proper erythropoiesis and show craniofacial and limb deformities similar to those observed in patients with Diamond-Blackfan anemia. The animals die in midgestation.  » Read more
05.05.2008  |  Anna Lena Marwedel      RSS Feed  Research News

Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T- Cell Development

Differentiation of class I-restricted thymocytes changed into CD4+CD8- helper-like T-cells, when Runx transcription factor complexes were absent. Usually, CD4+CD8+ double-positive thymocytes differentiate into CD4+ helper-lineage cells when expressing the transcription factor ThPOK, but without it they take the path of the cytotoxic CD8+ lineage.  » Read more
05.05.2008  |  Anna Lena Marwedel      RSS Feed  Research News

Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

Two nucleosome binding proteins with similar nucleosome-binding properties and similar modulating activities on promoter chromatin architecture proofed to play distinct roles in the determination of target gene transcription and thus the final gene expression in vivo.  » Read more
05.05.2008  |  Anna Lena Marwedel      RSS Feed  Research News


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