STAT6 antibody

Catalog No. ABIN969423

Product Details anti-STAT6 Antibody

Target: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This STAT6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purpose: STAT6 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human STAT6 expressed in E. Coli.

Clone: 7D3

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-STAT6 antibody (ABIN969423)

Ikeuchi, Kobayashi, Arakawa, Suzuki, Tamra, Morikawa: "Polymorphisms in interleukin-4-related genes in patients with minimal change nephrotic syndrome." in: Pediatric nephrology (Berlin, Germany), Vol. 24, Issue 3, pp. 489-95, (2009) (PubMed).

Inomata, Into, Nakashima, Noguchi, Matsushita: "IL-4 alters expression patterns of storage components of vascular endothelial cell-specific granules through STAT6- and SOCS-1-dependent mechanisms." in: Molecular immunology, Vol. 46, Issue 10, pp. 2080-9, (2009) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Target Details for STAT6

Target: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Alternative Name: STAT6 (STAT6 Products)

Background:

Description: STAT6 protein is a transcription factor activated by cytokines, particularly interleukin 4 and IL 13. (STAT6-/-) were found to be deficient in IL 4 mediated functions including Th2 helper T cell differentiation, expression of cell surface markers, T cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL 4 mediated proliferation. STAT6 mRNA has been detected in peripheral bloodlymphocytes, colon, intestine, ovary, prostate,thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response.

Aliases: STAT6B, STAT6C, D12S1644, IL-4-STAT, STAT6

Molecular Weight: 94kDa

Gene ID: 6778

HGNC: 6778

UniProt: P42226

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response