PEG10 antibody (AA 1-120)

Catalog No. ABIN969348

Product Details anti-PEG10 Antibody

Target: PEG10 (Paternally Expressed 10 (PEG10))

Binding Specificity: AA 1-120

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PEG10 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: PEG10 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of PEG10 (aa1-120) expressed in E. Coli.

Clone: 1B1C4

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PEG10 antibody (ABIN969348)

Kochetov, Ahmad, Ivanisenko, Volkova, Kolchanov, Sarai: "uORFs, reinitiation and alternative translation start sites in human mRNAs." in: FEBS letters, Vol. 582, Issue 9, pp. 1293-7, (2008) (PubMed).

Wang, Xiao, Hu, Chen, Liu, Hu: "PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma." in: FEBS letters, Vol. 582, Issue 18, pp. 2793-8, (2008) (PubMed).

Jie, Lang, Jian, Chaoqun, Dehua, Yi, Yanping, Luokun, Qiuping, Hui, Feili, Boquan, Youxin, Jinquan: "Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells." in: Oncogene, Vol. 26, Issue 39, pp. 5741-51, (2007) (PubMed).

Target Details for PEG10

Target: PEG10 (Paternally Expressed 10 (PEG10))

Alternative Name: PEG10 (PEG10 Products)

Synonyms: EDR antibody, HB-1 antibody, MEF3L antibody, Mar2 antibody, Mart2 antibody, RGAG3 antibody, AA407948 antibody, Edr antibody, MyEF-3 antibody, paternally expressed 10 antibody, PEG10 antibody, Peg10 antibody

Background:

Description: PEG10: paternally expressed 10. This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.

Aliases: Edr, HB-1, Mar2, MEF3L, Mart2, RGAG3, KIAA1051

Gene ID: 23089

HGNC: 23089

UniProt: Q86TG7