Thyroperoxidase antibody (Internal Region)

Catalog No. ABIN955202

Product Details anti-Thyroperoxidase Antibody

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Binding Specificity: Internal Region

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This Thyroperoxidase antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-TRHVIQVSNE VVTDD

Specificity: This antibody is expected to recognize reported isoforms a (NP_000538.3) and e (NP_783653.1).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_000538.3, NP_783650.1, NP_783652.1, NP_783653.1.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Abstract: TPO Products

Background: Thyroid peroxidase (TPO) is an enzyme expressed in the thyroid gland which is necessary for the production of thyroid hormes such as thyroxine. Congenital hypothyroidism and congenital goiter are both associated with mutations in the TPO gene.

Gene ID: 7173

NCBI Accession: NP_000538

Pathways: Thyroid Hormone Synthesis