FBXW12 antibody (C-Term)

Catalog No. ABIN952293

Product Details anti-FBXW12 Antibody

Target: FBXW12 (F-Box and WD Repeat Domain Containing 12 (FBXW12))

Binding Specificity: AA 298-328, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW12 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human FBXW12 (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 298-328 amino acids from the C-terminal region of Human FBXW12

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FBXW12

Target: FBXW12 (F-Box and WD Repeat Domain Containing 12 (FBXW12))

Alternative Name: FBXW12 (FBXW12 Products)

Background: Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1, MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].Synonyms: F-box and WD-40 domain-containing protein 12, F-box only protein 35, F-box/WD repeat-containing protein 12, FBW12, FBXO12, FBXO35

Molecular Weight: 53056 Da

Gene ID: 285231

NCBI Accession: NP_001153399