Complement Factor I antibody (Biotin)

Catalog No. ABIN951647

Product Details anti-Complement Factor I Antibody (Biotin)

Target: Complement Factor I (CFI)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Complement Factor I antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)

Specificity: Anti-human factor I (C3b inactivator) monoclonal antibody clone OX-21 recognizes human complement protein factor I. Factor I has two polypeptide chains, 56 kDa and 36 kDa. This antibody detects only the 56 kDa chain. This clone has been reported not to cross react with rat.

Immunogen: Human complement Factor I Donor: Immunized FI cross DBA/2 x BALB/c mouse spleen cells Fusion Partner: NS-1 mouse myeloma

Clone: OX-21

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0,1 mg/mL

Buffer: PBS containing 0.02 % sodium azide (NaN3) as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for Complement Factor I

Target: Complement Factor I (CFI)

Alternative Name: Complement Factor I (CFI Products)

Background: Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement protein breakdown products: Factor H, CR1 and MCP are required for C3b cleavage and C4bp or CR1 for C4b cleavage.Synonyms: AHUS3, C3B/C4B inactivator, C3BINA, C3b-INA, CFI, IF, KAF

Gene ID: 3426

NCBI Accession: NP_000195

UniProt: P05156

Pathways: Complement System