TLR1 antibody (N-Term)

Catalog No. ABIN951276

Product Details anti-TLR1 Antibody

Target: TLR1 (Toll-Like Receptor 1 (TLR1))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Purified

Immunogen: Peptide corresponding to 16 amino acids near the amino terminus of human TLR1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Target Details for TLR1

Target: TLR1 (Toll-Like Receptor 1 (TLR1))

Alternative Name: CD281 / TLR1 (TLR1 Products)

Background: Toll-like receptors (TLRs) are evolutionarily conserved patternrecognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5) so the organism can respond to potential infection. TLR1 is coexpressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells (6) where they form heterodimers that can recognize triacylated lipoproteins (7).Synonyms: KIAA0012, TIL, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein

Gene ID: 9606

UniProt: Q15399

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades