CARD16 antibody (N-Term)

Catalog No. ABIN951040

Product Details anti-CARD16 Antibody

Target: CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))

Binding Specificity: AA 44-73, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CARD16 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to COP1.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 44-73 amino acids from the N-terminal region of human COP1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CARD16

Target: CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))

Alternative Name: CARD16 / COP1 (CARD16 Products)

Background: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.Synonyms: CARD only domain-containing protein 1, Caspase recruitment domain-containing protein 16, Caspase-1 inhibitor COP, PSEUDO-ICE, Pseudo interleukin-1 beta converting enzyme

Molecular Weight: 22625 Da

Gene ID: 114769

NCBI Accession: NP_001017534