Histone 3 antibody (N-Term)

Catalog No. ABIN786552

Product Details anti-Histone 3 Antibody

Target: Histone 3 (H3)

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Histone 3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MARTKQTARK STGGKAPRKQ LATKVARKSA PATGGVKKPH RYRPGTVALR

Characteristics: This is a rabbit polyclonal antibody against HIST3H3. It was validated on Western Blot.

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HIST3H3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 136 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Histone 3

Target: Histone 3 (H3)

Alternative Name: HIST3H3 (H3 Products)

Synonyms: H-3 antibody, histocompatibility 3 antibody, H3 antibody

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
Alias Symbols: H3.4, H3/g, H3FT, H3t, MGC126886, MGC126888
Protein Interaction Partner: RAD6, SETD7, WHSC1L1, PRDM2, WHSC1, KMT2A, PHF7, CBX5, TRIM28, ING2, UBC, K07C5.3, APLF, UHRF1, NEDD8, CUL4A, EZH2, ASF1B, ASF1A, MMS22L, IGSF8, TONSL, ICAM1, CD81, AURKA, MLLT1, TAF8, TAF3, TAF9B, PHF21A, ING4, PRAME, KAT6B, CBX6, PHF8, PHF2, ITGA4, TAF1
Protein Size: 136

Molecular Weight: 15 kDa

Gene ID: 8290

NCBI Accession: NM_003493, NP_003484

UniProt: P84243