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SP1 antibody (C-Term)

SP1 Reactivity: Human WB, IF, IHC (p), FACS Host: Rabbit Polyclonal RB17350 unconjugated
Catalog No. ABIN655398
  • Target See all SP1 Antibodies
    SP1 (Sp1 Transcription Factor (SP1))
    Binding Specificity
    • 21
    • 12
    • 10
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 677-707, C-Term
    Reactivity
    • 88
    • 60
    • 39
    • 11
    • 8
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 90
    • 13
    • 3
    Rabbit
    Clonality
    • 83
    • 23
    Polyclonal
    Conjugate
    • 72
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SP1 antibody is un-conjugated
    Application
    • 91
    • 46
    • 45
    • 37
    • 21
    • 17
    • 14
    • 13
    • 11
    • 8
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Predicted Reactivity
    M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 677-707 amino acids from the C-terminal region of human SP1.
    Clone
    RB17350
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SP1 Primary Antibody
  • Application Notes
    IF: 1:10~50. WB: 1:500. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Zhang, Wang, Qin, Liu, Sun, Liu, Kuang, Jiang, Zhang: "cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression." in: PLoS ONE, Vol. 8, Issue 12, pp. e83097, (2014) (PubMed).

  • Target
    SP1 (Sp1 Transcription Factor (SP1))
    Alternative Name
    SP1 (SP1 Products)
    Background
    Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
    Molecular Weight
    80693
    Gene ID
    6667
    NCBI Accession
    NP_001238754, NP_003100, NP_612482
    UniProt
    P08047
    Pathways
    Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction
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