FCGR1A antibody (PE)

Catalog No. ABIN6253927

Product Details anti-FCGR1A Antibody (PE)

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FCGR1A antibody is conjugated to PE

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Fluorescence Microscopy (FM)

Specificity: CD64 reacts with the Fc gamma receptor 1 (FcγR1), a glycoprotein with a molecular weight of 72 kDa. The antigen is a high-affinity receptor for IgG and is able to bind human IgG1 and IgG3. The antigen is expressed on macrophages, monocytes, and interferon γ (IFN-γ) and Granulocyte Colony Stimulating Factor (G-CSF) stimulated neutrophils.

Purification: Ion exchange column

Clone: LPR-02

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C

Target Details for FCGR1A

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Alternative Name: CD64 (FCGR1A Products)

Background: Antigen distribution: This antibody binds to a CD64 epitope distinct from the ligand-binding site and from the clone 32.2 antibody to CD64 epitope. It shows especially high affinity binding to human mononuclear phagocytes and polymorphonuclear leukocytes exposed to IFN-γ or G-CSF. Its binding is not blocked in the presence of human IgG or immune complexes. Cellular Expression: Fc gamma receptor 1 on macrophages, monocytes and neutrophils.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process