CD16 antibody
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- Target See all CD16 Antibodies
- CD16
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD16 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Specificity
- B-E16 produces mouse IgG2a immunoglobulins specific for a 50-70 kD antigen which is associated with the IgG FceRI on NK cells, neutrophils, granulocytes and monocytes [3]
- Purity
- PURE
- Clone
- B-E16
- Isotype
- IgG2a
- Top Product
- Discover our top product CD16 Primary Antibody
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- Application Notes
- immunohistochemistry on cytospots, immunohistochemistry on frozen tissue
- Restrictions
- For Research Use only
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- Format
- Liquid
- Storage
- 4 °C
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- Target
- CD16
- Alternative Name
- CD16 (CD16 Products)
- Background
- Antigen distribution: CD16 is a low-affinity receptor for aggregated IgG (FcgRIII) [1,2]. The transmembrane form of CD16 is expressed on approximately 15% of peripheral blood lymphocytes and is present on virtually all resting NK cells. It is also found on macrophages and mast cells. It binds IgG complexed to antigens and mediates phagocytosis and antibody-dependent cellular cytotoxicity. On NK cells it mediates signal transduction while the GPI-linked form on neutrophils binds to ligands but is unable to induce any signal or functional effect [1]. Cellular Expression: NK cells, neutrophils, granulocytes, macrophages.
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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