CD80 antibody (FITC)

Catalog No. ABIN642339

Product Details anti-CD80 Antibody (FITC)

Target: CD80

Reactivity: Mouse

Host: Rat

Conjugate: This CD80 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: DS-MB-03886 recognizes mouse CD80 (B7-1), a 60kD cell surface glycoprotein which is a member of the CD28/B7 family. In mice, CD80 is expressed on monocytes, peritoneal macrophages and dendritic cells, and expression may be significantly increased upon B lymphocytes by LPS and by IL-4. CD80 has been identified as a ligand for CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4), two structurally similar molecules expressed on T cells. CD28 and CTLA4 are two receptors that have essential but opposing functions in T-cell stimulation. The Interaction of CD80 with CD28 stimulates and sustains T cell responses, whereas the interaction of CD80 with CTLA4 is reported to inhibit T-cell responses.

Characteristics: Rat Anti-Mouse CD80, FITC-labeled

Immunogen: BCL1 cells expressing CD80

Isotype: IgG2a

Application Details

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 0.1 mg/ml

Buffer: Phosphate buffered saline pH7.4

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for CD80

Target: CD80

Alternative Name: CD80 (CD80 Products)

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints